Clinical Report: Triglyceride-Glucose Index as a Predictor of Negative Cardiovascular Outcomes

Overview

This study investigates the relationship between the triglyceride-glucose (TyG) index and major adverse cardiovascular events (MACE) in patients with hypertension and obstructive coronary artery disease (OCAD). Findings indicate that an elevated TyG index is associated with an increased risk of MACE over a two-year follow-up period.

Background

Coronary artery disease (CAD) is a leading cause of cardiovascular mortality, with obstructive CAD (OCAD) presenting a higher risk for adverse outcomes. Hypertension frequently coexists with OCAD, exacerbating the prognosis. Identifying reliable prognostic markers, such as the TyG index, is crucial for effective risk stratification in this patient population.

Data Highlights

Key Findings

• 202 patients (19.73%) experienced MACE during the follow-up period.
• Each one-unit increment in the TyG index was linked with a 45.2% increased risk of MACE.
• The TyG index showed consistent predictive performance across various subgroups.
• A significant positive linear association was confirmed between the TyG index and MACE.
• Mendelian randomization analysis indicated a causal relationship between elevated TyG index and adverse cardiovascular outcomes.

Clinical Implications

Monitoring the TyG index may provide prognostic information for patients with hypertension and OCAD.

Conclusion

Elevated levels of the TyG index are strongly associated with worse clinical outcomes in patients with hypertension and OCAD, indicating its potential role as a prognostic tool.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Frontiers in Cardiovascular Medicine — Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients
3. Frontiers in Endocrinology — Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data
4. Frontiers in Cardiovascular Medicine — Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study
5. Frontiers in Endocrinology — Triglyceride-glucose index and subclinical left ventricular dysfunction across cardiovascular-kidney-metabolic syndrome stages: a 7-year retrospective cohort study
6. 2025 High Blood Pressure (BP) Guideline - Professional Heart Daily | American Heart Association
7. Triglyceride-glucose index and the risk of major adverse cardiovascular events in patients with coronary artery disease: A systematic review and meta-analysis - PubMed
8. https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-025-02813-6.pdf