Clinical Report: Distinct Mortality Risk Factors in MASLD and MetALD
Overview
This study investigates the mortality risk factors associated with metabolic-dysfunction-associated steatotic liver disease (MASLD) and its alcohol-related counterpart (MetALD). Findings indicate that both conditions are linked to increased all-cause mortality, with distinct risk profiles for each.
Background
MASLD and MetALD are significant public health concerns, affecting a substantial portion of the population and contributing to liver disease progression and mortality.
Data Highlights
Condition
All-Cause Mortality Rate
HR (95% CI)
p-value
MetALD
2.33%
2.085 (1.127–3.860)
0.019
MASLD
1.05%
2.610 (1.029–6.618)
0.043
Key Findings
Both MASLD and MetALD are associated with increased all-cause mortality compared to controls.
MetALD has a higher all-cause mortality rate (2.33%) than MASLD (1.05%).
Cancer-related mortality is significantly higher in both MASLD and MetALD groups.
Excessive alcohol intake and current smoking are independent predictors of mortality in the MetALD group.
In MASLD, being female and having a higher income are associated with lower mortality rates.
Each additional cardiometabolic risk factor (CMRF) in MASLD correlates with increased cardiovascular mortality (HR 1.838).
Clinical Implications
Healthcare professionals should consider the distinct risk factors associated with MASLD and MetALD when assessing patient mortality risk.
Conclusion
The study highlights the differing mortality risk profiles of MASLD and MetALD.
