Intracranial angiomatoid fibrous histiocytoma in a 2-month-old infant: a rare case report - Report - MDSpire

Intracranial angiomatoid fibrous histiocytoma in a 2-month-old infant: a rare case report

  • By

  • Xiaoyu Yang

  • Xiaofeng Chen

  • Yi Zhang

  • Yanming Ren

  • Junwen Guan

  • Ke Wu

  • June 15, 2026

  • 0 min

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Clinical Report: Intracranial occurrence of angiomatoid fibrous histiocytoma in a 2-month-old infant

Overview

This report describes a rare case of angiomatoid fibrous histiocytoma (AFH) occurring intracranially in a 2-month-old infant. The tumor was successfully diagnosed and excised, highlighting the need for careful management in such unusual presentations.

Background

Angiomatoid fibrous histiocytoma (AFH) is a rare mesenchymal tumor primarily found in the extremities or trunk, with intracranial occurrences being exceedingly rare, especially in infants. The unique presentation of AFH in this age group poses significant diagnostic and therapeutic challenges, necessitating a multidisciplinary approach for effective management.

Data Highlights

No numerical data available in the article.

Key Findings

['AFH is a rare tumor that typically arises in the extremities or trunk.', 'Intracranial AFH in infants is exceptionally rare, with limited prior cases reported.', 'The case involved a 4 × 3 × 4 cm epidural mass confirmed through imaging and histopathology.', 'Complete surgical resection is the gold-standard management for AFH.', 'Definitive diagnosis requires immunohistochemistry and molecular genetic testing.', 'Collaboration with pathologists is crucial for accurate diagnosis and treatment planning.']

Clinical Implications

Healthcare professionals should maintain a high index of suspicion for AFH in infants presenting with unusual masses. Early imaging and histopathological evaluation are essential for timely diagnosis and intervention.

Conclusion

This case underscores the rarity of intracranial AFH in infants and the importance of comprehensive diagnostic approaches to ensure effective management.

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