Clinical Report: Efficacy of Modified Meridian-Guided Acupoint Pressing in LFJ OA

Overview

This study investigates the efficacy of Modified Meridian-Guided Acupoint Pressing (MMGAP) in treating lumbar facet joint osteoarthritis (LFJ OA) using an animal model. Findings indicate significant reductions in inflammation and alterations in gut microbiota and serum metabolomic profiles.

Background

Lumbar facet joint osteoarthritis (LFJ OA) is a common cause of chronic low back pain, particularly in older adults. Current treatments often provide only temporary relief and can have adverse effects.

Data Highlights

Key Findings

• MMGAP significantly reduced inflammatory cell infiltration in lumbar muscles and facet joints.
• Serum levels of IL-1β and TNF-α were markedly downregulated.
• TRPV1 protein expression was reduced by over 40% at both mRNA and protein levels.
• MMGAP reshaped gut microbiota, enhancing diversity indices and altering β-diversity clustering.
• Fecal microbiota transplantation from MMGAP-treated rats replicated therapeutic effects.

Clinical Implications

Further exploration of MMGAP's mechanisms could enhance understanding of its role in managing degenerative joint diseases.

Conclusion

MMGAP alleviates LFJ OA through modulation of inflammatory responses and gut microbiota.

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