Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study - Report - MDSpire

Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study

  • By

  • Xinyu Tong

  • Jianxiong Gu

  • Chuxin Lyu

  • Yichun Zhao

  • Lei Chen

  • Tianzhi Ren

  • Haoxin Wu

  • Lei Yu

  • Ying Rui

  • June 29, 2026

  • 0 min

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Clinical Report: Relationship Between Hemoglobin Glycation Index and Large-Artery Atherosclerosis in Ischemic Stroke

Overview

This study investigates the association between the hemoglobin glycation index (HGI) and large-artery atherosclerosis (LAA) in ischemic stroke patients.

Background

Ischemic stroke (IS) is a leading cause of death and disability globally, with large-artery atherosclerosis (LAA) being a significant subtype. Understanding the risk factors associated with LAA is crucial. The hemoglobin glycation index (HGI) may serve as a tool for risk stratification in IS patients.

Data Highlights

CohortOdds Ratio (OR)p-value
MIMIC-IV0.579< 0.001
Clinical Cohort0.599< 0.001
MIMIC-IV (In-hospital mortality)0.488< 0.001

Key Findings

  • Lower HGI is associated with higher LAA risk in both MIMIC-IV and clinical cohorts.
  • In MIMIC-IV, lower HGI correlates with increased in-hospital mortality.
  • HGI demonstrated the highest feature importance among baseline variables analyzed.
  • HGI and stress hyperglycemia ratio (SHR) are strongly inversely correlated in both cohorts.
  • Higher SHR is associated with adverse outcomes.
  • Mendelian randomization did not show significant genetic evidence linking HGI to LAA.

Clinical Implications

The findings suggest that HGI may be a marker for assessing the risk of LAA and in-hospital mortality in ischemic stroke patients.

Conclusion

Lower HGI is linked to increased risks of LAA and in-hospital mortality in ischemic stroke.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- Association of HbA1c and comorbidities on stroke severity: insights from a cross-sectional analysis in a tertiary hospital
  2. Frontiers in Endocrinology, 2026 -- Association between hemoglobin glycation index and all-cause mortality in patients with non–ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
  3. Frontiers in Neurology, 2026 -- Prognostic Significance and Temporal Patterns of Glycemic Variability in Critically Ill Non-Diabetic Patients with Ischemic Stroke: A Retrospective Multicenter Cohort Study
  4. Diabetes Care in the Hospital: Standards of Care in Diabetes—2025 - PMC
  5. Fasting blood glucose-to-glycated hemoglobin ratio and functional outcomes in patients with ischemic stroke following endovascular treatment—a meta-analysis - PMC
  6. Frontiers in Neurology — Association between triglyceride glucose-body mass index and outcomes in patients with acute ischemic stroke: a retrospective secondary analysis of a prospective Korean cohort
  7. 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2025 - PMC
  8. Fasting blood glucose-to-glycated hemoglobin ratio and functional outcomes in patients with ischemic stroke following endovascular treatment—a meta-analysis - PMC
  9. Overview of Acute Ischemic Stroke Evaluation and Management - PMC

Original Source(s)

Association of the hemoglobin glycation index with the large-artery atherosclerosis subtype in ischemic stroke: a dual-cohort study

  • by Xinyu Tong, Jianxiong Gu, Chuxin Lyu, Yichun Zhao, Lei Chen, Tianzhi Ren, Haoxin Wu, Lei Yu, Ying Rui

  • June 29, 2026

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