Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation - Report - MDSpire
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Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation
Clinical Report: Analysis of Δ9-tetrahydrocannabinol Levels in Breast Milk
Overview
This study evaluates Δ9-THC concentrations in breast milk, saliva, and urine among postpartum women using cannabis. Findings indicate that Δ9-THC levels in breast milk decline rapidly after cessation of cannabis use, becoming non-quantifiable within the first week postpartum.
Background
The increasing prevalence of cannabis use among pregnant and postpartum women raises significant concerns regarding maternal and infant health. Understanding the pharmacokinetics of Δ9-THC in breast milk is crucial for providing evidence-based guidance to breastfeeding mothers who use cannabis. Current guidelines recommend avoiding cannabis during lactation due to potential risks to infants.
Data Highlights
Sample Type
Δ9-THC Concentration
Time Point
Breast Milk
Decreased over time, non-quantifiable by 1 week
24 hours, 48 hours, 1 week postpartum
Saliva
Generally low, often below LOQ
24 hours, 48 hours, 1 week postpartum
Urine (THC-COOH)
Progressively decreased but quantifiable
24 hours, 48 hours, 1 week postpartum
Key Findings
Δ9-THC concentrations in breast milk decreased rapidly after cannabis cessation.
Breast milk Δ9-THC became non-quantifiable within one week postpartum among abstinent participants.
Urinary THC-COOH concentrations remained quantifiable longer than breast milk Δ9-THC.
Salivary Δ9-THC concentrations were low and frequently below the limit of quantification.
Significant correlations were observed between breast milk Δ9-THC and salivary Δ9-THC at the first sampling stage.
No significant correlations were found at later stages of the study.
Clinical Implications
Healthcare providers should be aware of the rapid decline of Δ9-THC in breast milk following cannabis cessation.
Conclusion
The study suggests that further research is needed to confirm findings on Δ9-THC levels in breast milk.
by Miguel Sandonís, Maia Brik, Clara Ramirez, Laura Castellote, Anna Creus, Gemma Parramón, Anna Suy, Josep Antoni Ramos-Quiroga, Raul Felipe Palma-Álvarez, Constanza Daigre
