Beyond Functional Independence: Symptom Burden and Emotional Difficulties in Pediatric Long COVID — A Cross-Sectional Exploratory Study - Report - MDSpire

Beyond Functional Independence: Symptom Burden and Emotional Difficulties in Pediatric Long COVID — A Cross-Sectional Exploratory Study

  • By

  • Rodríguez-Pérez, Mª Pilar

  • HUERTAS-HOYAS, ELISABET

  • León-Herrera, Sandra

  • Gómez Bravo, Raquel

  • García-Bravo, Cristina

  • Rodríguez-Rodríguez, Esther

  • Poveda-García, Ana

  • June 24, 2026

  • 0 min

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Clinical Report: Exploring the Impact of Symptom Burden and Emotional Challenges in Pediatric Long COVID

Overview

This exploratory cross-sectional study highlights the significant symptom burden faced by children and adolescents with Long COVID. Participants exhibited substantial restrictions in school and recreational activities.

Background

Pediatric Long COVID presents unique challenges that can significantly impact the daily functioning of affected children and adolescents. Understanding the real-world implications of this condition is crucial.

Data Highlights

MeasureFindings
Symptom PrevalenceFatigue: 81.5%, Difficulty Concentrating: 63.0%, Malaise: 55.6%
Duration of Symptoms88.9% experienced symptoms for over 24 months
WeeFIM Total Score114.56 ± 20.71/126
School AttendanceOnly 18.5% attended school regularly
Grade Repetition11.1% had repeated an academic year
Withdrawal from Activities85.2% had withdrawn from previously enjoyed activities
SDQ Total Score12.07 ± 5.04 (normal range)
Emotional Symptoms Score5.59 ± 2.34 (slightly elevated)

Key Findings

  • High symptom burden with fatigue (81.5%), difficulty concentrating (63.0%), and malaise (55.6%) reported.
  • 88.9% of participants experienced symptoms lasting over 24 months.
  • Despite high symptom burden, WeeFIM scores indicated near-ceiling functional independence.
  • Only 18.5% of participants attended school regularly, with 11.1% repeating an academic year.
  • 85.2% of participants withdrew from previously enjoyed recreational activities.
  • A significant negative correlation was found between SDQ total score and WeeFIM cognition (rho = −0.570, p = 0.0019).

Clinical Implications

Standard functional independence measures may not adequately reflect the real-world impact of Long COVID in pediatric patients.

Conclusion

Children and adolescents with Long COVID may experience significant emotional and functional challenges. Further research is needed to explore these impacts.

Related Resources & Content

  1. World Health Organization, WHO, 2023 -- A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus
  2. JAMA Network, JAMA Pediatrics, 2025 -- Social Determinants of Health and Pediatric Long COVID in the US
  3. the asco post — Factors Influencing Symptom Burden in Pediatric Patients With Cancer: Insights From Routine Screening
  4. Open Forum Infectious Diseases — Association of Viral Load and Disease Severity in Acute SARS-CoV-2 Infection with the Development of Long COVID Symptoms
  5. Infection — Post-Acute Sequelae of SARS-CoV-2 in Pediatric Populations: A One-Year Analysis of Symptom Development and Recovery Using German Healthcare Data
  6. Open Forum Infectious Diseases — Health-Related Quality of Life Outcomes Two Years Post Mild to Moderate SARS-CoV-2 Infection During the Pre-Omicron Period
  7. A clinical case definition for post COVID-19 condition in children and adolescents by expert consensus, 16 February 2023
  8. Social Determinants of Health and Pediatric Long COVID in the US | Coronavirus (COVID-19) | JAMA Pediatrics | JAMA Network
  9. Cognitive and mental health outcomes in long covid | The BMJ

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