Clinical Report: Prognostic Significance of Systemic Inflammation Response Index in ALVOS

Overview

This study evaluates the association between baseline Systemic Inflammation Response Index (SIRI) and 90-day functional outcomes in patients with acute large vessel occlusion stroke (ALVOS) post-recanalization. No significant association with hemorrhagic transformation was found.

Background

Acute large vessel occlusion stroke (ALVOS) is a critical condition that often leads to significant morbidity and mortality. Despite advancements in endovascular therapy (EVT), many patients experience poor functional outcomes after successful recanalization. Identifying reliable prognostic indicators, such as the Systemic Inflammation Response Index (SIRI), is essential.

Data Highlights

Key Findings

• The mean age of the study cohort was 70.9 ± 13.0 years, with 58.5% being male.
• The mean SIRI level was significantly lower in the good outcome group compared to the poor outcome group (p < 0.001).
• The area under the ROC curve for SIRI predicting a poor outcome was 0.63 (95% CI: 0.56–0.69, P<0.001).
• Incorporating SIRI into the age + NIHSS model improved prognostic accuracy (AUC increase from 0.76 to 0.79, p = 0.023).
• No significant association was found between SIRI levels and hemorrhagic transformation (OR 1.08, p = 0.29).

Clinical Implications

SIRI may serve as a biomarker for predicting functional outcomes in ALVOS patients post-EVT.

Conclusion

Higher baseline SIRI levels are associated with poorer functional outcomes at 90 days in ALVOS patients after EVT, while no link to hemorrhagic transformation was established.

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