Clinical Report: Reference Ranges for GFAP and NfL in Healthy Subjects
Overview
This study establishes reference intervals for glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in a healthy population, accounting for biological modifiers such as age, sex, kidney function, and BMI. The findings provide a framework for interpreting GFAP and NfL concentrations in clinical settings, particularly in neurodegenerative diseases.
Background
GFAP and NfL are important biomarkers for astrocyte and neuronal injury, respectively, and their concentrations can indicate various neurological conditions. Understanding the normal reference ranges for these biomarkers is crucial for accurate diagnosis and monitoring of neurological diseases. This study addresses the need for comprehensive reference intervals that consider multiple biological factors influencing GFAP and NfL levels.
Data Highlights
{'GFAP': 'Insert established reference interval', 'NfL': 'Insert established reference interval'}
Key Findings
{'reference_intervals': 'Add specific reference intervals for GFAP and NfL.'}
Clinical Implications
{'examples': 'Include examples of how to interpret biomarker levels in specific neurological conditions.'}
Conclusion
The study successfully establishes reference ranges for GFAP and NfL, which are essential for clinical interpretation in neurological contexts. These findings contribute to the growing body of evidence supporting the use of these biomarkers in diagnosing and monitoring neurological diseases.
by Rebecca Z. Rousset, Madison I. J. Honey, Anouk den Braber, Wiesje M. van der Flier, Henne Holstege, Linda Lorenz, Mark H. J. Wessels, Joep Killestein, Martijn Huisman, Almar Kok, Marian Beekman, P. Eline Slagboom, Lannie Ligthart, Eco de Geus, Inge M. W. Verberk, Lisa Vermunt, Charlotte E. Teunissen
