The prevalence and risk factors of acute kidney injury in post-orthopedic surgery patients - Report - MDSpire

The prevalence and risk factors of acute kidney injury in post-orthopedic surgery patients

  • By

  • Wen Li

  • Chenfei Fu

  • Wenjing Fu

  • Aihua Zhang

  • June 29, 2026

  • 0 min

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Clinical Report: Investigating the Incidence and Contributing Factors of Acute Kidney Injury in Patients Following Orthopedic Surgery

Overview

This study investigates the prevalence and risk factors for acute kidney injury (AKI) in orthopedic surgery patients, finding an overall prevalence of 3.47%. Key risk factors identified include bone tumor surgery, preoperative proteinuria, and the use of certain medications.

Background

Acute kidney injury (AKI) is a significant complication following orthopedic surgery, associated with increased morbidity and prolonged hospital stays. The incidence of AKI in surgical patients is concerning, particularly in the context of rising prevalence rates.

Data Highlights

GroupAKI Prevalence
Overall3.47%
Bone Tumor Surgery11.36%
Spinal Surgery2.46%

Key Findings

  • AKI occurred in 97 out of 2,796 patients, resulting in a prevalence of 3.47%.
  • The highest incidence of AKI was observed in patients undergoing bone tumor surgery (11.36%).
  • Patients in the AKI stage 3 group had longer hospital stays compared to other groups (P < 0.001).
  • Independent risk factors for AKI included bone tumor surgery, preoperative proteinuria, elevated urea, decreased hemoglobin, and the use of PPIs and NSAIDs.
  • AKI is associated with significant morbidity and increased healthcare costs in orthopedic surgery patients.

Clinical Implications

Clinicians should be aware of the elevated risk of AKI in patients undergoing orthopedic surgery, especially those with bone tumors.

Conclusion

The study highlights the risk of AKI following orthopedic surgery, particularly in specific surgical contexts.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming
  2. Intensive Care Medicine, 2023 -- A Worldwide Examination of Postoperative Acute Kidney Injury Following Major Surgical Procedures: Essential Findings and Concerning Outcomes
  3. Intensive Care Medicine, 2025 -- Strategies for Preventing Postoperative Acute Kidney Injury
  4. Intensive Care Medicine, 2023 -- Global Study on the Incidence of Acute Kidney Injury Following Surgery (EPIS-AKI): A Prospective Multi-Center Observational Analysis
  5. KDIGO, 2026 -- KDIGO 2026 Clinical Practice Guideline for Acute Kidney Injury
  6. Prevalence and risk factors of acute kidney injury in patients with hip fractures - PubMed
  7. Topic
  8. Prevalence and risk factors of acute kidney injury in patients with hip fractures - PubMed

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