Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients - Report - MDSpire

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients

  • By

  • Molly Moore Jeffery

  • Fernanda Bellolio

  • Nancy Chang

  • Summer Allen

  • Marie-Carmelle Elie-Turenne

  • W. Jonathan Fillmore

  • Gregg H. Gilbert

  • Rebekah Heckmann

  • Patricia Koussis

  • Christine Lee

  • Heather Lipkind

  • Tamra E. Meyer

  • Teryl K. Nuckols

  • Jessica D. Ritchie

  • Michael A. Pacanowski

  • David B. Page

  • Mat Soukup

  • Stephen Tamang

  • Sam Torbati

  • Doug Wallace

  • Lauren Walter

  • Yueqin Zhao

  • Nilay D. Shah

  • Mitra Ahadpour

  • Joseph S. Ross

  • July 7, 2026

  • 0 min

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Opioid Administration and Pain Management Outcomes in Opioid-Naive Individuals

Overview

This study investigates opioid prescribing patterns and pain outcomes in opioid-naive patients with acute pain.

Background

Acute pain management remains a challenge in clinical practice, with opioids often prescribed despite guidelines recommending their use only for severe or refractory pain. There is a lack of high-quality evidence regarding the effectiveness of opioids compared to nonopioid treatments, complicating decision-making for healthcare providers. Understanding the patterns of opioid use in opioid-naive individuals is crucial for improving pain management outcomes.

Data Highlights

No numerical data was provided in the source material.

Key Findings

  • The study enrolled opioid-naive adults across various clinical settings, including emergency departments and dental practices.
  • Patients completed digital questionnaires assessing demographics, clinical history, and social determinants of health.
  • Enrollment prioritized underrepresented populations in acute pain management studies.
  • Opioids were prescribed as part of routine care for acute pain lasting less than 8 weeks.
  • Guidelines recommend reserving opioids for severe or refractory pain.

Clinical Implications

Healthcare providers should be aware of the guidelines recommending limited opioid use for acute pain.

Conclusion

The study highlights gaps in evidence regarding opioid use in acute pain management.

Related Resources & Content

  1. Journal of General Internal Medicine, 2026 -- Comparison of Patient-Reported Hospital Discharge Experiences in Patients with Long-Term and Episodic Opioid Therapy: A Qualitative Study
  2. Pain Medicine, 2026 -- Insights on: The Use of Buprenorphine for Managing Acute Pain in Elderly Patients: A Systematic Review and Meta-Analysis
  3. The ASCO Post, 2012 -- Pain Remains Prevalent and Often Inadequately Treated among Cancer Outpatients
  4. Pain Medicine, 2026 -- Comparative Analysis of Clinical and Psychological Profiles in Patients Undergoing Opioid Use Disorder Treatment Versus Those on Low- and High-Dose Opioids for Pain Management
  5. Updated European Society for Emergency Medicine Guidelines for acute pain management in emergency departments and prehospital care
  6. American Society of Anesthesiologists Guidelines & Clinical Guidelines Summaries
  7. Adult/Adolescent Acute Dental Pain Management for Toothaches | American Dental Association
  8. Systematic Review on Treatments for Acute Pain: Surveillance Report 2 - Treatments for Acute Pain: A Systematic Review
  9. Efficacy and Harms of Opioid Analgesics for Acute Pain: Overview of Systematic Reviews and Meta-analyses - PubMed
  10. The effect of adding a second multimodal analgesic component to anesthesia regimens on acute postoperative pain outcomes: a systematic review and meta-analysis | BMC Anesthesiology | Springer Nature Link
  11. FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain | FDA
  12. New persistent opioid use following surgery among opioid-naïve patients in the USA: a systematic review and meta-analysis of observational studies | Regional Anesthesia & Pain Medicine
  13. Patient-related risk factors for new persistent opioid use after surgery among opioid-naïve individuals in the United States: a systematic review and meta-analysis - PMC

Original Source(s)

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients

  • by Molly Moore Jeffery, Fernanda Bellolio, Nancy Chang, Summer Allen, Marie-Carmelle Elie-Turenne, W. Jonathan Fillmore, Gregg H. Gilbert, Rebekah Heckmann, Patricia Koussis, Christine Lee, Heather Lipkind, Tamra E. Meyer, Teryl K. Nuckols, Jessica D. Ritchie, Michael A. Pacanowski, David B. Page, Mat Soukup, Stephen Tamang, Sam Torbati, Doug Wallace, Lauren Walter, Yueqin Zhao, Nilay D. Shah, Mitra Ahadpour, Joseph S. Ross

  • July 7, 2026

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