Artificial intelligence in the radiologic assessment of ductal carcinoma in situ: a systematic review - Report - MDSpire

Artificial intelligence in the radiologic assessment of ductal carcinoma in situ: a systematic review

  • By

  • Colin Wu

  • Alison Bartak

  • Ramaswamy Sharma

  • July 14, 2026

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Clinical Report: Evaluating the Role of Artificial Intelligence in Radiologic Diagnosis of Ductal Carcinoma In Situ

Overview

This comprehensive review evaluates the role of artificial intelligence (AI) in enhancing the radiologic diagnosis of ductal carcinoma in situ (DCIS).

Background

Ductal carcinoma in situ (DCIS) represents a significant proportion of breast cancer diagnoses, with a notable risk of progression to invasive cancer. The limitations of traditional imaging modalities, particularly in dense breast tissue, highlight the need for improved diagnostic tools. AI has emerged as a potential solution to enhance the accuracy and efficiency of DCIS detection and management.

Data Highlights

MetricValue
AUC0.70 to 0.97
Sensitivity80–96%
Specificityup to 93%

Key Findings

  • AI technologies can enhance detection and classification of DCIS.
  • AI models demonstrate AUCs ranging from 0.70 to 0.97.
  • Sensitivities for AI in DCIS detection range from 80% to 96%.
  • Specificities for AI can reach up to 93%.
  • Temporal, multiphase, and spatially aware models outperform conventional 2D approaches.
  • Limitations include retrospective designs and generalizability concerns.

Clinical Implications

Further validation and standardization of AI tools are necessary to ensure their clinical applicability.

Conclusion

Careful consideration of AI's limitations and the need for further research is essential.

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  8. AI-based triage and decision support in mammography and digital tomosynthesis for breast cancer screening: a paired, noninferiority trial | Nature Medicine
  9. Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without AI in the MASAI study: a randomised, controlled, non-inferiority, single-blinded, population-based, screening-accuracy trial - ScienceDirect
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  11. Subgroup performance of a commercial digital breast tomosynthesis model for breast cancer detection | Nature Communications
  12. Frontiers | Artificial Intelligence in the Radiologic Assessment of Ductal Carcinoma In Situ: A Systematic Review
  13. Invasion prediction with artificial intelligence in ductal carcinoma in situ (DCIS) patients: a proof-of-concept study - PMC

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