Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Diagnostic Accuracy of Speckle Tracking Echocardiography in Identifying Coronary Artery Disease: A Systematic Review and Meta-Analysis

  • By

  • Linping Xu

  • Haoqi Xu

  • Zhi Pan

  • Ruizhong Ye

  • August 28, 2026

Share

Clinical Report: Diagnostic Accuracy of Speckle Tracking Echocardiography in CAD

Overview

This systematic review and meta-analysis evaluated the diagnostic performance of speckle tracking echocardiography (STE) in identifying coronary artery disease (CAD).

Background

Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally, necessitating accurate diagnostic strategies. Current standard diagnostic methods, such as coronary angiography, are invasive and carry risks.

Data Highlights

ParameterSensitivitySpecificity
Overall STE77.3% (95% CI: 73.4–80.8%)75.0% (95% CI: 71.5–78.1%)
GLS78.6% (95% CI: 74.5–82.2%)76.3% (95% CI: 72.7–79.7%)
GAS83.3% (95% CI: 74.5–89.5%)72.2% (95% CI: 58.9–82.5%)

Key Findings

  • STE sensitivity for CAD was 77.3% and specificity was 75.0%.
  • GLS showed a sensitivity of 78.6% and specificity of 76.3%.
  • GAS had the highest sensitivity at 83.3% but moderate specificity at 72.2%.
  • Exercise stress STE demonstrated greater sensitivity compared to dobutamine stress or no-stress protocols.
  • Overall evidence certainty was rated low due to high risk of bias and imprecision.

Clinical Implications

Clinicians should be aware of the moderate diagnostic accuracy and the need for further standardization in methodology.

Conclusion

Future studies should focus on standardizing methodologies and validating strain thresholds.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Diagnostic Accuracy of Speckle Tracking Echocardiography in Identifying Coronary Artery Disease: A Systematic Review and Meta-Analysis
  2. MDSpire News — Speckle Tracking Detects Early Diastolic Dysfunction in T2D
  3. MDSpire News — CT Scans Rival Echo for Aortic Stenosis
  4. Frontiers in Cardiovascular Medicine — Optimize speckle-tracking echocardiography screening in CKD patients: a TyG index-based nomogram model
  5. Clinical Research in Cardiology — Evaluating the Prognostic Utility of a Combined Clinical and Echocardiographic Risk Score for Predicting Cardiovascular Outcomes in Patients with Ischemic Heart Failure and Reduced Ejection Fraction
  6. Speckle Tracking Detects Early Diastolic Dysfunction in T2D
  7. CT Scans Rival Echo for Aortic Stenosis
  8. Optimize speckle-tracking echocardiography screening in CKD patients: a TyG index-based nomogram model
  9. 2024 Chronic Coronary Syndromes
  10. Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement From the American Society of Echocardiography
  11. Frontiers | Sensitivity and Specificity of Speckle Tracking Echocardiography for Coronary Artery Disease: a Systematic Review and Meta-Analysis

Original Source(s)

Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis

  • by Linping Xu, Haoqi Xu, Zhi Pan, Ruizhong Ye

  • August 28, 2026

Related Content

TOFA may drive weight loss without reducing food intake

The oral compound increased energy expenditure, reduced fat mass, and improved metabolic measures in male mouse models.

Baptist Health Heart & Vascular Care to Host 43rd Annual Echocardiography and Structural Heart Symposium

Baptist Health South Florida will host the Baptist Health Heart & Vascular Care 43rd Annual Echocardiography and Structural Heart Symposium on Oct. 2-3 at the Loews Coral Gables Hotel.

  • by

  • August 28, 2026

  • 4 min
Tirzepatide’s cardiovascular effects in clinical practice

Investigators compared cardiovascular outcomes with tirzepatide and a placebo proxy in patients with type 2 diabetes and established atherosclerotic cardiovascular disease.