Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study - Report - MDSpire
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Quality of Life, Mental Health, and Exercise Levels in Individuals with Mild to Moderate Ascending Aortic Dilation: A Cross-Sectional Case-Control Analysis

  • By

  • Fredrik Nilsson

  • Marcus Lindenberger

  • Sabina Borg

  • David Kylhammar

  • Petter Dyverfeldt

  • Filip Hammaréus

  • Lena Jonasson

  • Aleksandra Krzynska-Trzebiatowska

  • Lennart Nilsson

  • Chiara Trenti

  • Jan Engvall

  • Eva Swahn

  • September 21, 2026

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Quality of Life, Mental Health, and Exercise Levels in Individuals with Mild to Moderate Ascending Aortic Dilation

Overview

This study investigates health-related quality of life (HRQoL), psychological status, and physical activity levels in patients with mild to moderate ascending aortic dilation.

Background

Ascending aortic dilation poses significant health risks, including potential aortic dissection and rupture, necessitating ongoing surveillance and management. While surgical outcomes for thoracic aneurysms have been studied, the HRQoL and psychological impacts on conservatively managed patients with mild to moderate dilation remain underexplored.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

  • Patients with mild to moderate ascending aortic dilation report lower HRQoL compared to age- and sex-matched controls.
  • Psychological distress, including anxiety and depression, is prevalent among individuals with ascending aortic dilation.
  • Physical activity levels are affected by the condition.
  • Existing guidelines provide limited clarity on exercise restrictions for patients with mild to moderate dilation.
  • There is a relationship between cardiovascular disease and mental health.

Clinical Implications

Regular assessments of HRQoL and mental health may be beneficial in this patient population.

Conclusion

The study highlights the psychological and quality of life impacts of mild to moderate ascending aortic dilation.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic
  2. Pediatric Cardiology, 2019 -- Physical Performance in Asymptomatic Adults Following Treatment for Aortic Coarctation
  3. European Radiology, 2024 -- Correlation between aortic diameters and mortality rates in the general population: Insights from an MRI study
  4. Clinical Research in Cardiology, 2022 -- Longitudinal Study of Newly Developed Aortic Dilatation Over 25 Years in the General Population
  5. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease, Circulation -- A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
  6. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease, JACC -- A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
  7. Longitudinal health-related quality of life in people with thoracic aortic aneurysms - PMC
  8. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines | Circulation
  9. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines | JACC
  10. Longitudinal health-related quality of life in people with thoracic aortic aneurysms - PMC

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