Analysis of latent profiles of stressors and their influencing factors in patients with breast cancer undergoing postoperative chemotherapy: a mixed-methods study - Report - MDSpire
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Investigation of Hidden Stressor Profiles and Contributing Factors in Breast Cancer Patients Receiving Postoperative Chemotherapy: A Mixed-Methods Approach

  • By

  • Jingjing Chen

  • Tiantian Yang

  • Xiaoling Yan

  • August 21, 2026

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Clinical Report: Investigation of Hidden Stressor Profiles in Breast Cancer Patients

Overview

This study identifies four distinct stress profiles among breast cancer patients undergoing postoperative chemotherapy.

Background

Breast cancer is the most commonly diagnosed cancer in women, with a significant global burden. Postoperative chemotherapy introduces various stressors that can adversely affect patients' psychological well-being and quality of life.

Data Highlights

ProfilePercentage
Low-stress Adaptive Profile26.3%
Moderate-High Physio-Psychological Distress Profile38.4%
High Medical Concerns Profile20.3%
High-Stress Across Domains Profile15.1%

Key Findings

  • Four latent stress patterns were identified among patients: Low-stress Adaptive, Moderate-High Physio-Psychological Distress, High Medical Concerns, and High-Stress Across Domains.
  • Age was found to have a protective effect against higher stress profiles.
  • Stage III breast cancer significantly increased the likelihood of being classified in the High Medical Concerns and High-Stress Across Domains profiles.
  • Financial status, specifically a monthly income ≤5000 RMB, was associated with a higher likelihood of the High-Stress Across Domains profile.
  • Treatment-related complications were linked to increased stress levels in patients.
  • Qualitative interviews revealed themes around multiple stressors and the impact of external support systems.

Clinical Implications

Identifying patients' stress profiles can guide the provision of targeted psychosocial support. Enhanced information and decision-making aids are recommended for those in the High Medical Concerns Profile, while integrated interventions are suggested for patients in the High-Stress Across Domains Profile.

Conclusion

The study highlights the heterogeneous nature of stress experiences in breast cancer patients undergoing chemotherapy.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Potential profile analysis of return-to-work readiness and self-efficacy in postoperative breast cancer patients who have returned to work
  2. The Relationship Between Anxious Personality Traits and Quality of Life Outcomes Following Breast-Conserving Surgery for Breast Cancer
  3. Frontiers in Oncology, 2026 -- Symptom clusters and sentinel symptoms in colorectal cancer patients during post-operative chemotherapy
  4. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  5. Global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis - PubMed
  6. Frontiers in Psychiatry — Patterns and predictors of cognitive function and post-traumatic growth in cancer patients: a latent profile analysis
  7. NCCN Guidelines® Insights: Survivorship, Version 2.2025 - PubMed
  8. Communication and support of patients and caregivers in chronic cancer care: ESMO Clinical Practice Guideline - PMC
  9. NCCN Guidelines® Insights: Distress Management, Version 1.2026 - PubMed
  10. Survivorship Care for People Affected by Advanced or Metastatic Cancer: Building on the Recent Multinational Association of Supportive Care in Cancer-ASCO Standards and Practice Recommendations | American Society of Clinical Oncology Educational Book
  11. Global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis - PubMed
  12. Patient-Reported Quality of Life 6 Years After Breast Cancer | Oncology | JAMA Network Open | JAMA Network
  13. Mindfulness-integrated Cognitive Behavioral Therapy reduces pain and psychological distress, and improves equanimity, hope and post-traumatic growth during breast cancer treatment: A pilot randomized controlled trial - PubMed
  14. Identifying psychosocial distress phenotypes in postoperative patients with breast cancer: A latent profile analysis - ScienceDirect

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