Immune Regulation Influenced by Hormones Affects Asthma Variability Throughout Women's Lifespan
-
By
-
Qiaoyu Yang
-
Shucheng Hua
-
July 20, 2026
Clinical Report: Immune Regulation Influenced by Hormones Affects Asthma Variability
Overview
This review explores the impact of estrogen on asthma heterogeneity in females across their lifespan, highlighting the role of estrogen receptors in immune regulation.
Background
Asthma presents significant sex differences, with a higher prevalence in males during childhood that shifts to females post-puberty. Understanding the hormonal influences on asthma is crucial.
Data Highlights
No numerical data or trial data provided in the source material.
Key Findings
- Asthma prevalence shifts from males to females after puberty.
- Estrogen has complex effects on immune responses, promoting activation through ERα and exerting anti-inflammatory effects via ERβ.
- Non-type 2 inflammation is more prevalent in adult females.
- Environmental factors and comorbidities interact with hormonal signaling to shape asthma phenotypes in women.
- Estrogen's immunological effects vary with receptor subtype and hormone concentration.
Clinical Implications
Healthcare professionals should consider hormonal fluctuations and life-stage factors when managing asthma in females.
Conclusion
The interplay between estrogen and immune regulation is critical in understanding asthma variability in women.
Related Resources & Content
- Global Strategy for Asthma Management and Prevention, 2026 -- GINA 2026 Strategy Report
- Hormonal influences on asthma phenotypes and endotypes during the menopausal transition | American Journal of Physiology-Lung Cellular and Molecular Physiology | American Physiological Society, 2026
- Endocrine Variations Affect the Activity of Uveitis, The Ophthalmologist, 2025
- Perspective: Hormones and immune development: bidirectional regulation between thyroid hormones and the immune system, Frontiers in Immunology, 2026
- The immune microenvironment: a key regulator of ovarian function during ovarian aging, Frontiers in Immunology, 2026
- The Ophthalmologist — Endocrine Variations Affect the Activity of Uveitis
- conexiant — Sex Does Not Modify Asthma Attack Predictors
- Sex Does Not Modify Asthma Attack Predictors
- Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study
- Global Strategy for Asthma Management and Prevention
- Hormonal influences on asthma phenotypes and endotypes during the menopausal transition | American Journal of Physiology-Lung Cellular and Molecular Physiology | American Physiological Society
Based on findings from:
Hormone-dependent immune regulation shapes asthma heterogeneity across the female lifespan
Qiaoyu Yang, Shucheng Hua. Frontiers In Immunology, 2026.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1864024/full
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
