Clinical Report: Correction to a study of T-cell requirements in allergic airway inflammation
Overview
A 2006 Nature Medicine correction identifies an overlapping image in Fig. 2a and a genotype error in the article text. The notice states that the corrected genotype is H2-Kb−/−H2-Db−/−, alongside B2m−/− mice; it does not provide new experimental findings.
Background
The corrected article concerns whether natural killer T cells and CD8+ T cells are required for T cell–dependent allergic airway inflammation. The correction addresses the accuracy of a figure panel and a genotype designation in the original publication. These amendments clarify the published record but do not, in the supplied notice, report additional experiments or revise the study’s conclusions. The notice was published online on 1 December 2006.
Data Highlights
Item
Correction reported
Fig. 2a
Panels for C57BL/6 WT + CD8-depleted mice and C57BL/6 Cd1d1−/− + CD8-depleted mice overlapped in the initially published article.
Image provenance
The authors supplied a prior iteration of the C57BL/6 WT + CD8-depleted panel, which had appeared in an earlier manuscript version submitted to the journal.
Second paragraph
The genotype designation should read H2-Kb−/−H2-Db−/− rather than Axin1−/−Lepr−/−, alongside B2m−/− mice.
Publication date
Online publication: 1 December 2006.
Key Findings
The correction concerns the article titled “Natural killer T cells and CD8+ T cells are not required for T cell–dependent allergic airway inflammation.”
Two Fig. 2a panels representing different mouse conditions overlapped in the initially published version.
The overlapping panels were for C57BL/6 WT + CD8-depleted mice and C57BL/6 Cd1d1−/− + CD8-depleted mice.
The authors provided an earlier version of the C57BL/6 WT + CD8-depleted panel; it had been included in a prior manuscript version submitted to the journal.
The second paragraph’s genotype designation is corrected from Axin1−/−Lepr−/− to H2-Kb−/−H2-Db−/−, alongside B2m−/− mice.
The supplied correction notice reports amendments to the figure and text, not new experimental results.
Clinical Implications
This notice is relevant to interpretation and citation of the original article: readers should use the corrected Fig. 2a panel and genotype designation. The supplied correction does not provide a basis for additional clinical recommendations or conclusions beyond these record corrections.
Conclusion
The correction clarifies an overlapping figure panel and a genotype error in the original report. It does not describe new data or a change to the article’s stated subject.
