Clinical Report: Mapping the Global Research Landscape in Paraptosis
Overview
This bibliometric analysis identifies key trends and hotspots in paraptosis research. The study reveals that China is the leading contributor to this field, with a focus on mechanistic investigations and cancer-related research.
Background
Paraptosis is a non-canonical form of programmed cell death characterized by cytoplasmic vacuolation, distinct from classical apoptosis. The systematic mapping of paraptosis research can guide future studies.
Data Highlights
Metric
Value
Total Publications
401
Most Productive Country
China (n = 155)
Most Productive Institution
Ajou University (n = 19)
Core Author
Choi Kyeong Sook
Most Co-cited Author
Sperandio S (n = 356)
Key Findings
Paraptosis research has shown a fluctuating upward trend, especially from 2020 to 2025.
China is the leading country in paraptosis research output.
Key research hotspots include phenotypic identification and mechanistic investigations related to cancer.
Mechanistic studies focus on endoplasmic reticulum stress, mitochondrial damage, and reactive oxygen species accumulation.
Paraptosis has gained recognition as an independent research topic since 2018.
Clinical Implications
Continued research and international collaboration are essential for advancing the understanding of paraptosis.
Conclusion
Paraptosis research is evolving. Future studies should focus on mechanistic elucidation.
