Assessing the Effectiveness of the RACE Score in Distinguishing Stroke from Stroke Mimics in Emergency Department Settings - Report - MDSpire

Assessing the Effectiveness of the RACE Score in Distinguishing Stroke from Stroke Mimics in Emergency Department Settings

  • By

  • Hatice Yelda Yildiz

  • Kaan Gülcan

  • Süreyya Ece Kozbaǧ

  • İrem Özürün

  • Zeynep Demirkiran

  • Yakup Krespi

  • April 29, 2026

  • 0 min

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Clinical Report: Assessing the Effectiveness of the RACE Score in Stroke Evaluation

Overview

This study evaluates the RACE score's effectiveness in distinguishing true strokes from mimics in emergency settings. The findings indicate that higher RACE scores correlate with confirmed strokes and large vessel occlusion (LVO), suggesting its utility in acute stroke workflows.

Background

Rapid and accurate differentiation between true strokes and stroke mimics is crucial in emergency departments, as misclassification can lead to inappropriate treatment decisions. Stroke remains a leading cause of morbidity and mortality globally, necessitating effective diagnostic tools. The RACE score has emerged as a potential adjunct to clinical assessment in identifying LVO, which significantly impacts treatment outcomes.

Data Highlights

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Key Findings

  • The mean RACE score was significantly higher in stroke patients compared to stroke mimics (3.15 vs. 1.64, p < 0.001).
  • Patients with RACE scores ≥5 were more frequently diagnosed with stroke (30.8% vs. 8.8%, p < 0.001).
  • LVO was identified in 15.4% of patients, with higher RACE scores in these cases (4.59 vs. 1.85, p < 0.001).
  • Logistic regression indicated a significant association between higher RACE scores and the presence of LVO (OR 1.59, 95% CI 1.38–1.83, p < 0.001).
  • Older patients were more likely to be diagnosed with stroke compared to those with mimics (69.13 vs. 61.67 years, p = 0.001).

Clinical Implications

The RACE score can enhance the accuracy of stroke evaluations in emergency departments, aiding in the rapid identification of true strokes and LVO. Incorporating the RACE score into clinical workflows may improve patient outcomes by facilitating timely and appropriate interventions.

Conclusion

The RACE score serves as a valuable tool in differentiating strokes from mimics in emergency settings, with higher scores indicating a greater likelihood of LVO. Its integration into acute stroke protocols may optimize diagnostic accuracy and treatment efficacy.

References

  1. European Radiology, 2025 -- Forecasting Lesion Recovery in Acute Cerebral Ischemia Using Apparent Diffusion Coefficient Thresholds from Diffusion-Weighted MRI
  2. European Radiology, 2025 -- Influence of Motion Artifacts on MRI Image Quality in Stroke Assessment: Factors Affecting Diagnostic Accuracy for AI and Clinicians
  3. European Radiology, 2023 -- Baseline CT Imaging of Cortical Atrophy as a Predictor of Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Therapy
  4. American Heart Association, 2026 -- 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke
  5. PubMed, 2025 -- Prehospital Large-Vessel Occlusion Stroke Detection Scales: A Pooled Individual Patient Data Analysis of 2 Prospective Cohorts
  6. European Radiology — Collateral Mapping: Forecasting Lesion Expansion and Penumbral Area Following Acute Anterior Circulation Ischemic Stroke
  7. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke
  8. Prehospital Large-Vessel Occlusion Stroke Detection Scales: A Pooled Individual Patient Data Analysis of 2 Prospective Cohorts - PubMed
  9. The Incidence of Stroke Mimics in the Emergency Department of a Tertiary-care Center in Lebanon - PMC

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