Assessment of Delays in Diagnosis of Coeliac Disease Among Pediatric Patients: A Nationwide Multicenter Investigation in Turkey - Report - MDSpire

Assessment of Delays in Diagnosis of Coeliac Disease Among Pediatric Patients: A Nationwide Multicenter Investigation in Turkey

  • By

  • Yasin Sahin

  • Eylem Sevinc

  • Fatma Ilknur Varol

  • Ulas Emre Akbulut

  • Nevzat Aykut Bayrak

  • Aysegul Bukulmez

  • January 22, 2026

  • 0 min

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Clinical Report: Assessment of Delays in Diagnosis of Coeliac Disease in Turkey

Overview

This study investigates the median diagnostic delay of celiac disease (CD) in pediatric patients across Turkey, revealing a median delay of 7.3 months. The findings highlight the need for improved diagnostic strategies to reduce delays and associated complications.

Background

Celiac disease is a prevalent autoimmune disorder that can lead to significant health complications if not diagnosed early. The variability in clinical presentation often results in diagnostic delays, which can exacerbate conditions like malnutrition and osteoporosis. Understanding the factors contributing to these delays is crucial for improving patient outcomes.

Data Highlights

RegionPercentage of Patients
Southeastern Anatolia33.0%
Eastern Anatolia18.6%
Mediterranean18.1%
Marmara17.0%
Aegean8.5%
Black Sea4.8%

Key Findings

  • The median age of participants diagnosed with CD was 8.49 years.
  • The median delay from symptom onset to diagnosis was 7.30 months.
  • 8.5% of patients were diagnosed more than three years after the onset of symptoms.
  • There were no significant differences in diagnostic delays between different regions of Turkey.
  • Screening of high-risk, asymptomatic children was associated with shorter diagnostic delays.

Clinical Implications

Healthcare providers should be aware of the potential for significant diagnostic delays in pediatric celiac disease. Implementing targeted screening strategies for high-risk groups may facilitate earlier diagnosis and intervention, thereby reducing the risk of long-term complications.

Conclusion

The findings underscore the importance of timely diagnosis of celiac disease in children to prevent adverse health outcomes. Enhanced awareness and targeted screening could significantly improve diagnostic timelines.

References

  1. BMC Gastroenterology, 2023 -- Diagnostic delay in children with coeliac disease: a national multicentre study in Turkey
  2. The New Gastroenterologist, 2025 -- Increased Serological Markers Alone Do Not Confirm Celiac Disease Diagnosis
  3. The New Gastroenterologist, 2025 -- Celiac Disease: Recent Advances in Diagnosis and Patient Monitoring
  4. Journal of Gastroenterology, 2017 -- Detecting Celiac Disease in Asymptomatic Pediatric Patients: Insights from the Generation R Study
  5. Thomson, 2020 -- ESPGHAN Guidelines on Celiac Disease Diagnosis
  6. The Journal of Clinical Endocrinology & Metabolism — Association of Glucometabolic Parameters and Anti-Transglutaminase Antibodies at the Onset of Celiac Disease in Youth with Type 1 Diabetes
  7. Thomson
  8. Diagnostic delay in children with coeliac disease: a national multicentre study in Turkey | BMC Gastroenterology | Springer Nature Link
  9. Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease

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