Autohemotherapy combined with other external treatments of Traditional Chinese Medicine for chronic urticaria: a systematic review and meta-analysis - Report - MDSpire
Advertisement
Autohemotherapy combined with other external treatments of Traditional Chinese Medicine for chronic urticaria: a systematic review and meta-analysis
Clinical Report: Efficacy and Safety of Autohemotherapy for Chronic Urticaria
Overview
This systematic review and meta-analysis evaluate the efficacy and safety of autohemotherapy (AHT) combined with Traditional Chinese Medicine (TCM) external treatments for chronic urticaria (CU). The intervention group showed significant improvements in overall response rate, recurrence rate, serum IgE levels, pruritus severity, and wheal duration compared to the control group.
Background
Chronic urticaria (CU) is a recurrent skin condition that significantly impacts patients' quality of life and mental health. Current treatments primarily involve second-generation antihistamines, but many patients do not achieve adequate control. Exploring additional treatment options, such as AHT combined with TCM, is essential for improving patient outcomes.
Data Highlights
Outcome
Intervention Group
Control Group
RR/SMD (95% CI)
p-value
Overall Response Rate
Better
Standard Treatment
1.17 (1.10–1.24)
< 0.001
Recurrence Rate
Lower
Standard Treatment
0.31 (0.23–0.42)
< 0.001
Serum IgE Level
Lower
Standard Treatment
−1.33 (−1.76 to −0.91)
< 0.001
Pruritus Severity
Lower
Standard Treatment
−1.36 (−2.17 to −0.54)
< 0.001
Wheal Duration
Lower
Standard Treatment
−3.05 (−6.05 to −0.06)
< 0.005
Key Findings
The overall response rate was significantly better in the intervention group (RR: 1.17; p < 0.001).
The intervention group showed a significantly lower recurrence rate (RR: 0.31; p < 0.001).
Serum IgE levels were significantly reduced in the intervention group (SMD: −1.33; p < 0.001).
Pruritus severity showed significant improvement (SMD: −1.36; p < 0.001), though results were not robust.
Wheal duration was significantly reduced (SMD: −3.05; p < 0.005), but results showed significant publication bias.
Clinical Implications
The findings suggest that AHT combined with TCM external treatments may offer a beneficial alternative for patients with chronic urticaria who do not respond adequately to conventional therapies. However, the methodological limitations and high clinical heterogeneity among studies warrant cautious interpretation of these results.
Conclusion
Autohemotherapy combined with TCM external treatments appears to improve clinical efficacy and reduce recurrence rates in chronic urticaria. Further rigorous studies are needed to confirm these findings.
