Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy: A Case Study - Report - MDSpire

Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy: A Case Study

  • By

  • Inês Coelho-Costa

  • Rita Rodrigues

  • Amândio Rocha-Sousa

  • Susana Penas

  • Luís Figueira

  • Sónia Torres-Costa

  • January 29, 2026

  • 0 min

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Clinical Report: Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy

Overview

This case study presents a 37-year-old female with acute zonal occult outer retinopathy who was ultimately diagnosed with neurosarcoidosis after developing bilateral panuveitis and cranial neuropathies. The patient responded well to corticosteroid treatment, highlighting the importance of considering neurosarcoidosis in similar clinical presentations.

Background

Expand on the prevalence and specific symptoms associated with neurosarcoidosis.

Data Highlights

Incorporate qualitative data or comparisons to similar cases for better context.

Key Findings

  • A 37-year-old female presented with bilateral photopsia and paracentral scotoma.
  • Initial examination revealed bilateral optic disc edema and vitreous haze.
  • Further investigation showed elevated angiotensin-converting enzyme titers and granulomatous inflammation consistent with sarcoidosis.
  • The patient improved significantly with corticosteroids and methotrexate, achieving 20/20 vision bilaterally.
  • Neurosarcoidosis should be considered in patients with unexplained ocular symptoms and neurological deficits.

Clinical Implications

Highlight the need for differential diagnosis in patients with ocular and neurological symptoms.

Conclusion

Reinforce the importance of early intervention and ongoing monitoring for patient outcomes.

References

  1. Author(s)/Org, Source, Year -- Title
  2. Optometric Management — Neo or Not Neo? Widefield OCT-A Reveals Hidden Neovascularization
  3. Optometric Management — CLINICAL: Case Scenario
  4. Ophthalmology Management — ‘Real world’ OCT: Subtle findings, critical implications
  5. Retinal Physician — Ocular Toxoplasmosis as the Presenting Sign of AIDS
  6. Neo or Not Neo? Widefield OCT-A Reveals Hidden Neovascularization
  7. CLINICAL: Case Scenario
  8. 'Real world' OCT: Subtle findings, critical implications
  9. Consensus Recommendations for the Management of Neurosarcoidosis: A Delphi Survey of Experts Across the United States - PubMed
  10. Consensus Recommendations for the Management of Neurosarcoidosis | SRNA Blog
  11. Sarcoid Uveitis Epidemiology, Systemic Treatment, and Complications: A Large United States National Database Study: Ocular Immunology and Inflammation: Vol 34 , No 2 - Get Access

Original Source(s)

Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy: A Case Study

  • by Inês Coelho-Costa, Rita Rodrigues, Amândio Rocha-Sousa, Susana Penas, Luís Figueira, Sónia Torres-Costa

  • January 29, 2026

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