From Nodal Metastasis to Oncologic Recurrence in Tongue and Oral Floor Squamous Cell Carcinoma: Distinct Failure Patterns and Clinicopathological Risk Profiles - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Patterns of Failure and Risk Profiles in Tongue and Oral Floor Squamous Cell Carcinoma: Insights from Nodal Metastasis to Oncologic Recurrence

  • By

  • Jannik Ketschau

  • Jonathan Mohr

  • Alex Grabenhorst

  • Hannes Singer

  • Helena Kram

  • Cornelius Leopold

  • Nils Krautkremer

  • Katharina Pippich

  • Klaus-Dietrich Wolff

  • Lucas M. Ritschl

  • June 9, 2026

Share

Clinical Report: Patterns of Failure and Risk Profiles in Tongue and Oral Floor SCC

Overview

This study investigates the patterns of failure and risk profiles in patients with oral squamous cell carcinoma (OSCC) of the tongue and floor of mouth. It highlights the distinct clinicopathological factors associated with local, ipsilateral, and contralateral nodal recurrences.

Background

Oral squamous cell carcinoma (OSCC) poses significant challenges in treatment due to the risk of recurrence despite surgical interventions. Understanding the patterns of nodal metastasis and recurrence is crucial. This study aims to clarify the pathological predictors of recurrence in OSCC, particularly in the context of nodal involvement.

Data Highlights

No numerical or trial data provided in the source material.

Key Findings

  • Regional nodal recurrences in OSCC predominantly occur on the ipsilateral side, particularly involving level II lymph nodes.
  • Contralateral nodal recurrence is less common but noted in advanced lesions or those near the midline.
  • Pathological findings at primary surgery may predict distinct patterns of subsequent failure.
  • Nodal parameters such as lymph node ratio (LNR) and extranodal extension are associated with recurrence risk.
  • Local, ipsilateral, and contralateral nodal recurrences may represent distinct disease processes.

Clinical Implications

The findings indicate that assessment of pathological features at the time of primary surgery may inform the risk of recurrence in OSCC.

Conclusion

This study provides insights into the patterns of recurrence in OSCC.

Related Resources & Content

  1. Frontiers in Oncology, 2026 -- Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures
  2. conexiant -- Mutational Signatures May Define Oral Cancers
  3. Frontiers in Oncology, 2026 -- Prognostic model for three-year postoperative local recurrence in cutaneous squamous cell carcinoma: a Chinese multicenter cohort study
  4. AJCC 8th Edition Staging of Oral Cavity Cancer: Radiologic Evaluation - PMC
  5. Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer | New England Journal of Medicine
  6. Frontiers in Immunology — Stratified Lymph Node Yield Thresholds After Neoadjuvant Immunochemotherapy: A Surgical Benchmark for Survival in Oral Squamous Cell Carcinoma
  7. NCCN Guidelines for Head and Neck Cancers
  8. Neck Dissections Based on Sentinel Lymph Node Navigation Versus Elective Neck Dissections in Early Oral Cancers
  9. AJCC 8th Edition Staging of Oral Cavity Cancer: Radiologic Evaluation - PMC
  10. Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer | New England Journal of Medicine
  11. Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck | New England Journal of Medicine
  12. Histopathological predictors of lymph node metastasis in oral cavity squamous cell carcinoma: a systematic review and meta-analysis - PubMed
  13. Lymph node ratio (LNR) and lymph node yield (LNY) in head and neck cancer: A systematic review and meta-analysis - ScienceDirect
  14. Patterns of lymph node involvement for oral cavity squamous cell carcinoma - ScienceDirect
  15. From Nodal Metastasis to Oncologic Recurrence in Tongue and Oral Floor Squamous Cell Carcinoma: Distinct Failure Patterns and Clinicopathological Risk Profiles - PubMed

Original Source(s)

From Nodal Metastasis to Oncologic Recurrence in Tongue and Oral Floor Squamous Cell Carcinoma: Distinct Failure Patterns and Clinicopathological Risk Profiles

  • by Jannik Ketschau, Jonathan Mohr, Alex Grabenhorst, Hannes Singer, Helena Kram, Cornelius Leopold, Nils Krautkremer, Katharina Pippich, Klaus-Dietrich Wolff, Lucas M. Ritschl

  • June 9, 2026

Related Content

CAR T Before Surgery Improves Glioblastoma Control in Mice

Study finds that tumor resection creates a more immunosuppressive environment and that earlier CAR T cell treatment prolongs survival

  • September 7, 2026

  • 3 min
Retraction Note: Lycorine inhibits angiogenesis by docking to PDGFRα

AI-Designed Binder Improves CAR T Cell Activity in Mice

Researchers screened 1,758 de novo protein binders and identified design features that influence CAR T cell activation, specificity, and tumor control

  • September 15, 2026

  • 3 min