Comparative Analysis of Urban Exposome and Skin Microbiome in Atopic Dermatitis Across Two Brazilian Cities

By
Heloísa Silva de Avó Freixo
Hélio Amante Miot
Marília Marufuji Ogawa
Ivanka Miranda de Castro Martins
Vânia Rodrigues Leite e Silva
Newton Andreo Filho
Patrícia Santos Lopes
Romualdo Morandi Filho
Ediléia Bagatin
September 17, 2026

Dermatology And Therapy

Overview

This study compares the skin microbiome of atopic dermatitis patients from two Brazilian municipalities with differing pollution levels.

Background

Atopic dermatitis (AD) is a chronic inflammatory skin condition influenced by environmental factors and the skin microbiome. Understanding the relationship between urban pollution and skin microbiome dysbiosis is crucial for elucidating the pathophysiology of AD.

Data Highlights

No significant differences in overall bacterial diversity were observed between municipalities or age groups. However, patients from the metropolitan area showed significantly greater relative abundance of Staphylococcus aureus compared to those from the interior municipality.

Key Findings

Patients from the metropolitan municipality exhibited higher Staphylococcus aureus relative abundance.
No differences in overall bacterial diversity were found between the two municipalities.

Clinical Implications

Clinicians should consider the impact of urban environmental factors on the skin microbiome when managing atopic dermatitis.

Conclusion

The study presents findings on the effects of urban pollution on skin microbiome dynamics in atopic dermatitis patients.

Comparative Analysis of Urban Exposome and Skin Microbiome in Atopic Dermatitis Across Two Brazilian Cities