Retraction: Effectiveness of medical ozone injections into the intervertebral disc on relieving lumbosacral pain–a systematic review and meta-analysis - Report - MDSpire
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Withdrawal: A Systematic Review and Meta-Analysis on the Efficacy of Ozone Injections in the Intervertebral Disc for Alleviating Lumbosacral Pain

  • August 27, 2026

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Clinical Report: Withdrawal of Ozone Injections for Lumbosacral Pain

Overview

The systematic review and meta-analysis on the efficacy of ozone injections for lumbosacral pain has been retracted due to concerns regarding its scientific validity. The retraction was approved by the Chief Editors of Frontiers in Pain Research after an investigation found that the article did not meet the journal's editorial and scientific standards.

Background

Ozone therapy has been explored as a treatment for various pain conditions, including lumbosacral pain. The retraction of this article highlights the importance of maintaining rigorous standards in clinical research, as the article was found to have significant issues regarding its scientific validity.

Data Highlights

No numerical data is available due to the article's retraction.

Key Findings

  • The article was retracted due to valid complaints about its scientific validity.
  • Concerns were raised regarding the article's adherence to editorial and scientific standards, leading to an investigation.
  • The retraction was approved by the Chief Editors of Frontiers in Pain Research.
  • The authors agreed to the retraction following the investigation.
  • The retraction emphasizes the need for quality control in clinical research publications.

Clinical Implications

Healthcare professionals should be aware of the retraction and the need for rigorous validation in studies concerning ozone injections for pain management.

Conclusion

The retraction of this systematic review serves as a reminder of the importance of scientific integrity in medical research.

Related Resources & Content

  1. Cao D, Li X, Zhang X, Tian Y, Gu W, Zhu X, Yuan H, Frontiers in Pain Research, 2026 -- Withdrawal of Ozone Injections for Lumbosacral Pain
  2. Frontiers in Pain Research — The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis
  3. Efficacy of Intra-Articular Corticosteroid Injections for Treating Lumbar Disc Herniation: A Comprehensive Review and Meta-Analysis
  4. Frontiers in Neurology — Efficacy and safety of ozone autohemotherapy for zoster-associated pain: a meta-analysis and trial sequential analysis
  5. MDSpire News — AAN: Limited Benefits Found for Epidural Steroid Injections
  6. Regulatory and guideline landscape on ozone therapy
  7. Frontiers | Efficacy of ozone with steroid injection therapy in lumbar disc herniation: meta-analysis
  8. Spondylodiscitis Following Oxygen-Ozone Therapy: A Case Report of Lactobacillus iners Infection and a Systematic Literature Review.

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