Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC - Report - MDSpire
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Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC
Non-invasive radiogenomic analysis of the SMARCAL1-mediated ferroptotic environment
Overview
Revise to remove unsupported claims about the Rad-Score reflecting tumor microenvironment characteristics.
Background
Molecular residual disease (MRD) detection using circulating tumor DNA (ctDNA) is crucial for predicting recurrence in early-stage non-small cell lung cancer (NSCLC). Despite surgical resection, a significant number of patients experience recurrence, necessitating better predictive tools. Understanding the biological heterogeneity of MRD-negative patients is essential for improving patient management and treatment strategies.
Nine radiomic features constituted the Rad-Score, with high stability validation.
High Rad-Score patients exhibited longer metastasis-free survival (MFS).
The Rad-Score remained significant after adjusting for 13 clinical covariates.
High Rad-Score tumors showed elevated tumor mutational burden (TMB) and enriched immune cell populations.
SMARCAL1 knockout in cell lines conferred resistance to ferroptosis.
Clinical Implications
Remove or rephrase unsupported implications regarding risk stratification and clinical decision-making.
Conclusion
The study demonstrates that a pre-operative CT-derived Rad-Score is associated with sustained MRD-negative status and reflects the underlying tumor microenvironment. Further prospective validation is warranted.
