Clinical Report: Influence of Parental Age and Age Difference on Neonatal Health Outcomes
Overview
This study investigates the relationship between parental age, age differences, and neonatal health outcomes in a cohort of mother-infant pairs. Findings indicate that both maternal and paternal ages are associated with neonatal diseases, with nonlinear relationships observed.
Background
Understanding the impact of parental age on neonatal health is crucial for preconception counseling and perinatal risk assessment. Advanced maternal and paternal ages have been associated with increased risks of adverse neonatal outcomes, as shown in various studies.
Data Highlights
Group
Odds Ratio (OR)
95% Confidence Interval (CI)
Father-older
1.561
1.203–3.201
Mother-older
1.652
1.323–2.343
Maternal age
1.080
P < 0.001
Paternal age
1.051
P = 0.002
Key Findings
Both father-older and mother-older groups had increased odds of neonatal diseases compared to the equal-age group.
After adjusting for individual parental ages, the association for the father-older group became non-significant.
Maternal age and paternal age were identified as risk factors for neonatal outcomes.
Interactions were found between age gap and maternal age, as well as between maternal and paternal ages.
The risk of adverse neonatal outcomes increased after maternal age >30.1 years and paternal age >40.2 years.
Clinical Implications
Clinicians should consider both maternal and paternal ages during preconception counseling and perinatal risk assessments.
Conclusion
The study indicates that both maternal and paternal ages are associated with neonatal diseases, highlighting the need for consideration of parental age in clinical practice.
