Refractive Errors Identified Through Screening in Infants Conceived via Assisted Reproductive Technology: Findings from a Prospective Cohort Analysis

By
Xin Zou
Mamoud Alieu Jalloh
Zijin Wang
Yan Zong
Yangqian Jiang
Tao Jiang
Lei You
Rui Qin
Hong Lv
Yuxin Liu
Tianyu Sun
Bo Xu
Xiumei Han,
Xiaoyu Liu
Kun Zhou
Guangfu Jin
Hongxia Ma
Yuan Lin
Zhibin Hu
Hu Liu
Jiangbo Du
Jiong Li
March 30, 2026

Archives Of Gynecology And Obstetrics

Overview

This study investigates the association between assisted reproductive technology (ART) and the risk of refractive errors (REs) in infants at one year of age. Findings suggest that ART conception may not significantly increase the risk of screening-detected REs compared to spontaneously conceived infants.

Background

Assisted reproductive technology (ART) accounts for approximately 2% of live births and has been associated with various health risks in offspring, including potential visual development issues. Understanding the impact of ART on early visual development is crucial, as refractive errors can affect long-term visual outcomes. This study aims to clarify the relationship between ART and refractive errors in infants, contributing to the broader understanding of ART-related health implications.

Data Highlights

No significant increase in refractive errors was detected in ART-conceived infants compared to those conceived spontaneously.

Key Findings

ART conception does not appear to increase the risk of refractive errors at one year of age.
Variability in infertility-related diagnoses and ART procedures may influence visual outcomes.
The study included a large cohort of 2739 ART-conceived and 3574 spontaneously conceived infants.
Follow-up assessments were conducted to ensure accurate data collection on visual health.
Results indicate the need for cautious interpretation of ART-related visual development risks.

Clinical Implications

Healthcare providers should be aware that ART may not inherently increase the risk of refractive errors in infants. Ongoing monitoring and standardized screening protocols are essential for early detection and management of visual issues in this population.

Conclusion

The findings of this study provide reassurance regarding the visual health of ART-conceived infants, emphasizing the importance of continued research in this area.