Venous malformation with localized intravascular coagulopathy in children treated with sclerotherapy and LWMH - Report - MDSpire

Venous malformation with localized intravascular coagulopathy in children treated with sclerotherapy and LWMH

  • By

  • Xiao Gao

  • Xuming Wang

  • Yuhua Wei

  • Shuai Niu

  • Le Yang

  • Lei Xu

  • July 1, 2026

  • 0 min

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Clinical Report: Localized Intravascular Coagulopathy in Pediatric Venous Malformations

Overview

This study investigates localized intravascular coagulopathy (LIC) in pediatric patients with venous malformations (VMs), reporting that 44.8% of patients experienced LIC. Sclerotherapy combined with low-molecular-weight heparin (LMWH) was used in severe cases.

Background

Localized intravascular coagulopathy is a complication in pediatric venous malformations, often influenced by the hemostatic characteristics of children. Understanding LIC is important for management, as it can lead to bleeding tendencies despite localized thrombosis.

Data Highlights

ParameterValue
Number of patients116
Patients with LIC51 (44.8%)
LIC Severity38 mild, 11 moderate, 2 severe

Key Findings

  • LIC was present in 44.8% of pediatric VM patients.
  • Severity of LIC correlated with lesion burden.
  • All severe LIC cases were associated with extensive VMs involving ≥2 joint planes.
  • Sclerotherapy is used for managing LIC.
  • LMWH serves as a perioperative therapy.

Clinical Implications

Routine screening for LIC in pediatric patients with unexplained coagulopathy is suggested.

Conclusion

The findings highlight the importance of recognizing and managing LIC in pediatric venous malformations.

Related Resources & Content

  1. Frontiers in Pediatrics, 2026 -- Efficacy of interventions in peripheral arterial and venous malformations of the limbs in children: protocol for a systematic review
  2. Frontiers in Pediatrics, 2026 -- Case Report: Clinical management of genital, perineal, and perianal venous malformation in a five-year-old boy: therapeutic decision-making and review of current literature
  3. The Clinical Significance of Venous Sinus Stenting in Pediatric Idiopathic Intracranial Hypertension: A Review of Current Evidence
  4. Classification | International Society for the Study of Vascular Anomalies
  5. Frontiers | Venous malformation(VM) with localized intravascular coagulopathy (LIC) in children treated with sclerotherapy and LWMH
  6. Vascular Medicine — Images in Vascular Medicine: Endovascular recanalization for postthrombotic syndrome in a duplicated inferior vena cava anomaly
  7. Classification | International Society for the Study of Vascular Anomalies
  8. Frontiers | Venous malformation(VM) with localized intravascular coagulopathy (LIC) in children treated with sclerotherapy and LWMH
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Original Source(s)

Venous malformation with localized intravascular coagulopathy in children treated with sclerotherapy and LWMH

  • by Xiao Gao, Xuming Wang, Yuhua Wei, Shuai Niu, Le Yang, Lei Xu

  • July 1, 2026

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