A Controlled Comparison of Human and AI-Assisted Automated Revision of Delphi Statements on RNA-Based Medicines: Parallel, 2-Arm Study - Report - MDSpire

A Controlled Comparison of Human and AI-Assisted Automated Revision of Delphi Statements on RNA-Based Medicines: Parallel, 2-Arm Study

  • By

  • Enrico Nello

  • Fabio Tedone

  • Elena Caproni

  • Davide Cafiero

  • Sara Manellari

  • Paolo Rocco

  • July 13, 2026

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Clinical Report: A Comparative Analysis of Human and AI-Supported Automated Revisions

Overview

This study compares consensus outcomes from human and AI-assisted revisions of Delphi statements on RNA-based therapeutics.

Background

The Delphi method is widely used in health sciences to achieve expert consensus, particularly in areas lacking empirical evidence. However, traditional Delphi processes face challenges such as time consumption and panelist engagement. With the rapid advancement of RNA-based therapeutics, timely consensus statements are crucial for guiding regulatory and clinical practices.

Data Highlights

No numerical data or trial data were provided in the source material.

Key Findings

  • The Delphi method is effective for eliciting expert judgment but has limitations in time and engagement.
  • RNA-based therapeutics have gained prominence, particularly with mRNA vaccines for COVID-19.
  • AI-assisted methods can potentially streamline the consensus process in Delphi studies.
  • Large language models (LLMs) have shown promise in medical knowledge retrieval and summarization.

Clinical Implications

The integration of AI in the Delphi process may enhance the efficiency of developing consensus statements in RNA therapeutics. Clinicians and regulators could leverage AI tools to facilitate timely decision-making in this rapidly evolving field.

Conclusion

AI-assisted revisions in Delphi studies represent a promising advancement in achieving expert consensus on RNA-based therapeutics, potentially addressing existing limitations in traditional methods.

Related Resources & Content

  1. Clayton MJ, Educ Psychol, 1997 -- Delphi: a technique to harness expert opinion for critical decision‐making tasks in education
  2. Shang Z, Medicine (Baltimore), 2023 -- Use of Delphi in health sciences research: a narrative review
  3. Skerritt JH, Vaccines (Basel), 2025 -- Considerations for mRNA product development, regulation and deployment across the lifecycle
  4. Ke YH et al., NPJ Digit Med, 2025 -- Retrieval augmented generation for 10 large language models and its generalizability in assessing medical fitness
  5. Jin Q et al., J Am Soc Nephrol, 2023 -- Retrieve, summarize, and verify: how will ChatGPT affect information seeking from the medical literature?
  6. npj Digital Medicine — ARTEMIS: A Pilot Investigation of AI-Driven Versus Expert Treatment Choices in Simulated Cases of Neuroendocrine Neoplasms
  7. aace endocrine ai — How to read an AI study like a peer reviewer
  8. asco ai in oncology — Clinical Staff Using Natural Language Processing Model Enhances Accuracy of Clinical Trial Prescreening Process
  9. the medicine maker — Why Copilots Failed in R&D and What Comes Next
  10. COVID-19 Vaccines (2025-2026 Formula) for Use in the United States Beginning in Fall 2025 | FDA
  11. Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments - PMC
  12. RNA-targeting therapies for amyloid transthyretin cardiomyopathy: A systematic review and meta-analysis - ScienceDirect

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