Clinical Report: Misdiagnosis and Management in Primary Cutaneous DLBCL
Overview
This case study highlights the frequent misdiagnosis of primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL) in an elderly patient. The patient underwent treatment involving orthopedic debridement and R-miniCHOP immunochemotherapy, resulting in complete resolution of skin lesions.
Background
Primary cutaneous diffuse large B-cell lymphoma (PC-DLBCL) is a rare and aggressive form of non-Hodgkin lymphoma that often presents with nonspecific skin symptoms, leading to misdiagnosis. This condition primarily affects elderly patients, who may experience severe complications due to delayed treatment.
Data Highlights
No numerical data or trial data presented in the article.
Key Findings
PC-DLBCL is frequently misdiagnosed due to its nonspecific cutaneous manifestations.
The patient was initially misdiagnosed with skin allergy, skin cancer, and pemphigus.
Multidisciplinary management involving orthopedic and hematology-oncology specialists was essential for effective treatment.
The patient underwent orthopedic debridement, autologous skin grafting, and R-miniCHOP immunochemotherapy.
Complete resolution of skin lesions was achieved without recurrence at 7-month follow-up.
Clinical Implications
Early pathological biopsy is critical for accurate diagnosis of PC-DLBCL. Collaborative care between specialties is essential for effective treatment.
Conclusion
This case underscores the importance of recognizing PC-DLBCL to prevent misdiagnosis and ensure timely, effective treatment through multidisciplinary collaboration.
