Longitudinal trajectories of hematological indices and serum metalloproteinases-2 and 9 over 1 year after moderate and severe COVID-19 - Report - MDSpire

Longitudinal trajectories of hematological indices and serum metalloproteinases-2 and 9 over 1 year after moderate and severe COVID-19

  • By

  • Rebecca Salomão

  • Gabriel Pasquarelli-do-Nascimento

  • Mayara Ananias

  • Victoria Assis

  • Leandro Gomes de Jesus Ferreira

  • Isabella da Silva Almeida

  • Leandra Silva

  • Katiane Tostes

  • Bruna Pereira Sorroche

  • Lidia Maria Rebolho Batista Arantes

  • Kelly Grace Magalhães

  • Liliana Torcoroma García

  • Rochelle Rocha Costa

  • João Luiz Quagliotti Durigan

  • Rita de Cássia Marqueti

  • June 12, 2026

  • 0 min

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Year-long Analysis of Hematological Parameters and Serum Metalloproteinases-2 and 9 Following Moderate to Severe COVID-19

Overview

This study investigates the long-term effects of moderate to severe COVID-19 on hematological parameters and serum metalloproteinases over one year. Findings indicate persistent immune dysregulation and systemic inflammation, particularly in severe cases, highlighting the need for ongoing monitoring and potential interventions.

Background

The COVID-19 pandemic has resulted in significant long-term health consequences, with many individuals experiencing persistent symptoms after recovery from the acute phase. Understanding the biological markers associated with these long-term effects is crucial for developing targeted interventions and improving patient outcomes. This study provides valuable insights into the hematological and inflammatory changes that may persist long after the initial infection.

Data Highlights

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Key Findings

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Clinical Implications

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Conclusion

The findings underscore the need for ongoing research into the long-term effects of COVID-19, particularly regarding immune and inflammatory responses. Understanding these dynamics is essential for improving patient care and outcomes in the post-acute phase of COVID-19.

Related Resources & Content

  1. Clinical Research in Cardiology, 2020 -- Increased thrombo-inflammatory markers as predictors of outcomes in COVID-19 patients with cardiovascular comorbidities: findings from the LEOSS registry
  2. Blood Cancer Journal, 2021 -- Mid-term Outcomes and Features of COVID-19 Patients with Hematological Disorders: A Retrospective Analysis from a French Tertiary Care Facility
  3. Infection, 2024 -- Endothelial Impairment and Cardiovascular Risk Assessment in Post-COVID-19 Individuals Six and Twelve Months Following SARS-CoV-2 Infection
  4. Infection, 2022 -- Evaluation of Coagulopathy and Hemostatic Markers Related to COVID-19: A Study from a Single Center in Egypt
  5. Long COVID Clinical Guidance | Long COVID | CDC, 2026 -- Clinical guidance on Long COVID management
  6. BMC Infectious Diseases, 2025 -- Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19
  7. PubMed, 2023 -- Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization
  8. Long COVID Clinical Guidance | Long COVID | CDC
  9. Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 | BMC Infectious Diseases | Springer Nature Link
  10. Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization - PubMed

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