Potential implications of a therapeutic polyherbal infusion in Ayurveda as an adjunct to multidisciplinary relaxing techniques in alcohol withdrawal syndrome—an exploratory randomized study protocol - Report - MDSpire

Potential implications of a therapeutic polyherbal infusion in Ayurveda as an adjunct to multidisciplinary relaxing techniques in alcohol withdrawal syndrome—an exploratory randomized study protocol

  • By

  • Adiveppal Nandini

  • Muraleedharan Devi

  • Esanamangalam Meera

  • Chandran Haritha

  • S. Sandeep

  • Leena Parameswaran Nair

  • May 27, 2026

  • 0 min

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Clinical Report: Exploring Polyherbal Ayurvedic Infusion in Alcohol Withdrawal

Overview

This study protocol aims to evaluate the efficacy of a polyherbal infusion, Kharjuradi Mantha, as an adjunct to relaxation techniques for managing alcohol withdrawal syndrome (AWS). It hypothesizes that this approach will enhance symptom resolution and psychological stability in patients with mild-to-moderate AWS.

Background

Alcohol withdrawal syndrome (AWS) is a significant clinical concern associated with alcohol use disorders, leading to severe neuropsychological symptoms during early abstinence. Current pharmacological treatments primarily involve benzodiazepines, which may have adverse effects and do not adequately address psychological aspects of withdrawal. Integrating alternative therapies, such as Ayurvedic approaches, may provide a holistic strategy for managing AWS.

Data Highlights

This study protocol outlines a randomized controlled trial involving 38 male inpatients diagnosed with mild-to-moderate AWS, comparing the effects of a herbal infusion combined with relaxation techniques against relaxation techniques alone.

Key Findings

  • The study will assess the efficacy of Kharjuradi Mantha in managing AWS symptoms.
  • Participants will be evaluated using the Clinical Institute Withdrawal Assessment for Alcohol–Revised (CIWA-AR) score.
  • The trial aims to demonstrate improved psychological stability in patients receiving the herbal infusion.
  • Current management strategies primarily rely on benzodiazepines, which may not address psychological domains of AWS.
  • Ayurveda emphasizes treating root causes rather than symptoms, aligning with holistic treatment principles.

Clinical Implications

The integration of Ayurvedic treatments with standard care may offer a complementary approach to managing AWS. This study could provide insights into alternative therapies that address both physical and psychological aspects of withdrawal.

Conclusion

This exploratory study seeks to evaluate the potential benefits of a polyherbal infusion in conjunction with relaxation techniques for individuals experiencing AWS, contributing to the understanding of holistic management strategies.

Related Resources & Content

  1. Frontiers in Psychiatry, 2026 -- A Comprehensive Approach to Managing Alcohol Withdrawal Syndrome and Alcohol Dependence with Anxiety in Indian Patients: Insights from a Narrative Review
  2. BMC Psychiatry (Springer), 2025 -- Exploring the Efficacy of Virtual Reality Therapy in Treating Depression Among Adolescents: A Prospective Observational Analysis
  3. Journal of Medical Internet Research (JMIR), 2026 -- Effect of Integrated Internet-Based Acceptance and Commitment Therapy and Behavioral Activation Among Ethnic Minority Young Adults With Alcohol Use Disorder in Hong Kong: Pilot Randomized Controlled Trial
  4. Frontiers in Psychiatry, 2026 -- Context-Dependent Interaction Between Oxytocin Gene Polymorphisms and Alcohol Dependence in Modulating Negative Emotions During Acute Alcohol Withdrawal in Adult Males
  5. ASAM Clinical Practice Guideline, 2024 -- Clinical Practice Guideline on Alcohol Withdrawal
  6. Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis - PubMed, 2024
  7. CLINICAL PRACTICE GUIDELINE
  8. Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis - PubMed

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