A Case Report of Primary Mucinous Adenocarcinoma of the Bladder and Literature Review - Report - MDSpire

A Case Report of Primary Mucinous Adenocarcinoma of the Bladder and Literature Review

  • By

  • Li, Yue

  • Peng, Xuefeng

  • Jin, Suiyang

  • Wang, Qiang

  • June 22, 2026

  • 0 min

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Clinical Report: A Case Study of Primary Mucinous Adenocarcinoma in the Bladder

Background

Primary mucinous adenocarcinoma of the bladder is a rare and aggressive cancer, necessitating careful differentiation from metastatic gastrointestinal adenocarcinoma. The lack of standardized treatment protocols complicates management, making accurate diagnosis and individualized treatment essential.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

  • Primary mucinous adenocarcinoma of the bladder is rare and aggressive.
  • Diagnosis requires exclusion of metastatic gastrointestinal adenocarcinoma.
  • A targeted immunohistochemical panel was used for diagnosis: CK7–, CK20+, CDX2+, β-catenin membrane+, SATB2–, GATA3–.
  • The patient underwent transurethral resection followed by robot-assisted radical cystectomy.
  • No recurrence or metastasis was detected at 6-month follow-up.

Clinical Implications

Clinicians should be aware of the complexities in treatment decisions due to the absence of established guidelines.

Conclusion

This case study highlights the diagnostic challenges and treatment complexities of primary mucinous adenocarcinoma of the bladder.

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  4. World Journal of Urology (Springer) -- A molecular landscape tracking the progression of non-muscle invasive bladder cancer
  5. Primary adenocarcinoma of the urinary tract and its precursors: Diagnostic criteria and classification - ScienceDirect
  6. Primary adenocarcinoma of the urinary tract and its precursors: Diagnostic criteria and classification - ScienceDirect
  7. https://urology.wiki/Guidelines/Cancers/NCCN/2026/%EF%BC%882026.V1%EF%BC%89NCCN%20%E4%B8%B4%E5%BA%8A%E5%AE%9E%E8%B7%B5%E6%8C%87%E5%8D%97%EF%BC%9A%E8%86%80%E8%83%B1%E7%99%8C.pdf
  8. https://d56bochluxqnz.cloudfront.net/documents/EAU-Guidelines-on-Muscle-Invasive-Bladder-Cancer-2025.pdf
  9. Genetic characteristics and targeted treatments of primary bladder and urachal adenocarcinomas: a systematic review with pooled descriptive genomic analyses | Cancer and Metastasis Reviews | Springer Nature Link

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