Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes - Report - MDSpire
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Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes
Clinical Report: Evaluating the Relationship Between Serum IQGAP3 Levels, Triglyceride Glucose-Body Mass Index, and Coronary Lesion Severity in Patients with Type 2 Diabetes
Overview
This study investigates the association between serum IQGAP3 levels, triglyceride glucose-body mass index (TyG-BMI), and coronary lesion severity in patients with type 2 diabetes mellitus (T2DM). Findings indicate that both IQGAP3 and TyG-BMI are independently associated with severe coronary stenosis.
Background
Type 2 diabetes mellitus (T2DM) is linked to increased risk of coronary artery disease (CAD), necessitating effective biomarkers for risk assessment. The study explores IQGAP3, a protein involved in inflammatory processes, and TyG-BMI, a marker of insulin resistance, as potential indicators of coronary lesion severity.
Data Highlights
Measure
Value
Number of Patients
392
IQGAP3 OR for severe coronary stenosis
3.119 (95% CI: 2.049–4.747)
TyG-BMI OR for severe coronary stenosis
1.012 (95% CI: 1.003–1.021)
AUC for traditional model
0.702
AUC with TyG-BMI
0.753
AUC with IQGAP3
0.803
Key Findings
Serum IQGAP3 levels and TyG-BMI significantly increased across Gensini score tertiles (P< 0.05).
Both IQGAP3 and TyG-BMI were independently associated with severe coronary stenosis.
Incorporating TyG-BMI into traditional risk models improved discrimination (AUC: 0.702 vs. 0.753).
Further inclusion of IQGAP3 increased the AUC to 0.803 and improved reclassification metrics.
Age modified the association between IQGAP3 and severe coronary stenosis (Pinteraction = 0.036).
Clinical Implications
The findings indicate that serum IQGAP3 and TyG-BMI are associated with coronary lesion severity in T2DM patients.
Conclusion
Serum IQGAP3 and TyG-BMI are independently associated with coronary lesion severity in T2DM patients.
