Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis - Report - MDSpire

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis

  • By

  • Yan, Shang

  • Xue, Kai

  • Wang, Yinan

  • Jia, Desheng

  • Chen, Yong-chao

  • Lai, Xueyou

  • Zhao, Chunrui

  • Pan, Hongguang

  • Zeng, Nan

  • April 13, 2026

  • 0 min

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Clinical Report: Alterations in Glutamine Metabolism Correlate with M2 Macrophage Polarization in Allergic Rhinitis

Overview

Revise to specify the nature of nasal behavioral responses influenced by dietary glutamine supplementation.

Background

Allergic rhinitis is a prevalent condition characterized by type 2 immune responses, yet its chronic nature suggests complex regulatory mechanisms. Understanding the metabolic influences on immune cell function in AR is crucial for developing targeted therapies. This study explores the role of glutamine metabolism in shaping the immune microenvironment in AR.

Data Highlights

No numerical data available in the source material.

Key Findings

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Clinical Implications

The findings suggest that glutamine metabolism may play a significant role in the immune response in allergic rhinitis, potentially guiding new therapeutic strategies. Clinicians should consider the metabolic state of patients when evaluating immune responses and treatment options.

Conclusion

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Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming
  2. npj Digital Medicine, 2025 -- Comprehensive Multi-Omics Analysis of SNP-Driven Immunometabolic Profiles in Alzheimer’s Disease Unveils a New Predictive Model for Individuals
  3. Basic Research in Cardiology, 2016 -- Interactions Between Macrophages and Atrial Myocytes in Atrial Fibrillation
  4. Gastric Cancer, 2021 -- Interaction between cancer-associated fibroblasts and immune cells in peritoneal metastasis: Tranilast's role in reducing M2 macrophage and mast cell migration
  5. Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments, UCL Discovery
  6. Frontiers, 2026 -- Efficacy of allergen-specific immunotherapy for allergic rhinitis: a meta-analysis
  7. Frontiers, 2026 -- Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis
  8. Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments - UCL Discovery
  9. Frontiers | Efficacy of allergen-specific immunotherapy for allergic rhinitis: a meta-analysis
  10. Frontiers | Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis

Original Source(s)

Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis

  • by Yan, Shang , Xue, Kai , Wang, Yinan , Jia, Desheng , Chen, Yong-chao , Lai, Xueyou , Zhao, Chunrui , Pan, Hongguang , Zeng, Nan

  • April 13, 2026

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