American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy - Report - MDSpire
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American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy

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  • August 14, 2026

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Clinical Report: American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy

Overview

The American Epilepsy Society has released updated guidelines for managing epilepsy in infants and children aged 1 month to <36 months, emphasizing evidence-based recommendations. Key recommendations include strong surgical options for drug-resistant epilepsy.

Background

Infantile epilepsy presents unique challenges in management due to the limited high-quality data available for this age group. The updated guidelines aim to provide clinicians with evidence-based recommendations for pharmacologic, dietary, and surgical treatments.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • Strong surgical recommendations include hemispherectomy or hemispherotomy for specific unilateral lesional etiologies.
  • Focal, multilobar, or posterior disconnection surgeries are recommended for drug-resistant focal or lesional epilepsy.
  • Conditional recommendations for the ketogenic diet in drug-resistant epilepsy were made, highlighting feasibility and access issues.
  • Evaluation in experienced multidisciplinary pediatric centers is emphasized for optimal management.
  • Infantile spasms and West syndrome were excluded from these guidelines due to existing disorder-specific guidelines.

Clinical Implications

Clinicians should consider the updated guidelines when managing epilepsy in infants and young children, particularly regarding surgical options for drug-resistant cases.

Conclusion

The updated guidelines from the American Epilepsy Society provide a comprehensive framework for managing infantile epilepsy.

Related Resources & Content

  1. Freedman D, et al., Epilepsy Curr, 2026 -- American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy
  2. MDSpire News — Experts Weigh In: Navigating Epilepsy Treatment During Pregnancy
  3. MDSpire News — AAN Issues Guideline on Functional Seizures
  4. Frontiers in Neurology — Neonatal status epilepticus: critical issues in clinical practice
  5. Intensive Care Medicine — Incidence and Outcomes of Seizures in 204 Unconscious Pediatric Patients
  6. American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy - PMC
  7. Comparative efficacy of the classical ketogenic diet and modified Atkins diet in children with drug-resistant epilepsy: A systematic review and meta-analysis - Seizure - European Journal of Epilepsy
  8. Epilepsies in children, young people and adults - NCBI Bookshelf
  9. Impact of epilepsy surgery on developmental trajectories of children under 3 years of age - Wu - 2024 - Developmental Medicine & Child Neurology - Wiley Online Library
  10. Surgery for Drug-Resistant Epilepsy in Children | New England Journal of Medicine

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