Retraction Note: Atovaquone inhibits colorectal cancer metastasis by regulating PDGFRβ/NF-κB signaling pathway - Report - MDSpire

Notice of Retraction: The Role of Atovaquone in Modulating Colorectal Cancer Metastasis via the PDGFRβ/NF-κB Signaling Pathway

  • By

  • Bin Liu

  • Xin Zheng

  • Jiajun Li

  • Peng Yao

  • Peng Guo

  • Wei Liu

  • Gaoping Zhao

  • July 20, 2026

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Clinical Report: Notice of Retraction: The Role of Atovaquone in Modulating Colorectal Cancer Metastasis

Background

The integrity of published research is crucial for advancing clinical knowledge and practice. Retractions due to data issues can impact ongoing research, particularly in complex fields like oncology. Understanding the reasons behind such retractions is essential for maintaining scientific rigor.

Data Highlights

No numerical or trial data is available due to the retraction of the article.

Key Findings

  • The article was retracted due to significant issues with data integrity.
  • Resemblances were identified between multiple figures, raising concerns about the validity of the findings.
  • The authors were unable to adequately address the concerns raised by the editors.
  • Trust in the data and findings was diminished by the editors following the investigation.

Clinical Implications

Healthcare professionals should be aware of the retraction and the associated data integrity issues. This incident underscores the necessity for rigorous data validation in research to ensure reliable clinical applications.

Conclusion

The retraction of this article serves as a reminder of the importance of data integrity in scientific research and its implications for clinical practice.

Related Resources & Content

  1. BMC Cancer, 2023 -- Notice of Retraction: The Role of Atovaquone in Modulating Colorectal Cancer Metastasis via the PDGFRβ/NF-κB Signaling Pathway
  2. Journal of Neuro-Oncology — Retraction Note: MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma
  3. Frontiers in Oncology — Retraction: MTA1 promotes hepatocellular carcinoma progression by downregulation of DNA-PK-mediated H1.2T146 phosphorylation
  4. Journal of Neuro-Oncology (Springer) — Retraction Note: Mst1 regulates glioma cell proliferation via the AKT/mTOR signaling pathway
  5. Frontiers in Oncology — Retraction: Enhancer RNA SLIT2 inhibits bone metastasis of breast cancer through regulating P38 MAPK/c-Fos signaling pathway
  6. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
  7. NFκB signalling in colorectal cancer: Examining the central dogma of IKKα and IKKβ signalling

Original Source(s)

Retraction Note: Atovaquone inhibits colorectal cancer metastasis by regulating PDGFRβ/NF-κB signaling pathway

  • by Bin Liu, Xin Zheng, Jiajun Li, Peng Yao, Peng Guo, Wei Liu, Gaoping Zhao

  • July 20, 2026

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