Treatment as Prevention and HIV Transmission in the US - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Utilizing Antiretroviral Therapy for HIV Prevention and Transmission Reduction in the United States

  • By

  • Laura Matrajt

  • Sarah E. Stansfield

  • Mia Moore

  • Deborah J. Donnell

  • Elizabeth R. Brown

  • Myron S. Cohen

  • Dobromir Dimitrov

  • August 21, 2026

Share

Clinical Report: Utilizing Antiretroviral Therapy for HIV Prevention and Transmission Reduction

Background

Antiretroviral therapy (ART) has been shown to significantly lower sexual HIV transmission, leading to major revisions in HIV treatment guidelines. The principle of undetectable = untransmittable (U=U) has become a cornerstone of HIV prevention strategies. However, recent reports indicate potential reductions in AIDS drug assistance programs, which could jeopardize progress made in controlling the HIV epidemic.

Data Highlights

No numerical data available in the source material, but qualitative findings indicate significant impacts of ART on HIV transmission.

Key Findings

  • ART can substantially lower sexual HIV transmission, as demonstrated in landmark clinical trials.
  • When viral suppression is achieved, there is no sexual transmission of HIV among partners.
  • Reductions in access to ART could lead to increased HIV infections in the U.S., as indicated by modeling studies.
  • Counterfactual modeling suggests that diminished ART access may reverse the successes of treatment as prevention (TasP).
  • PrEP has been effective in reducing HIV transmission rates since its introduction.

Clinical Implications

Maintaining viral suppression is essential for preventing sexual transmission of HIV.

Conclusion

Access to ART is critical for sustaining progress in HIV prevention and control in the United States.

Related Resources & Content

  1. MDSpire News, MDSpire News, 2023 -- HIV Prevention Landscape Shifts: PrEP Study Insights
  2. JAMA Network Open, JAMA Network Open, 2023 -- HIV Preexposure Prophylaxis Prescriptions Among Black and Hispanic or Latino Populations
  3. Drug Safety, Drug Safety, 2017 -- Safety Issues Surrounding Pre-Exposure Prophylaxis for HIV Prevention
  4. Antiretroviral Therapy for the Prevention of HIV-1 Transmission - PMC, PMC, 2016 -- Antiretroviral Therapy for the Prevention of HIV-1 Transmission
  5. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV - ClinicalInfo.HIV.gov, NCBI Bookshelf, 2026 -- Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV
  6. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society–USA Panel | HIV | JAMA | JAMA Network, JAMA Network, 2024 -- Antiretroviral Drugs for Treatment and Prevention of HIV in Adults
  7. the medicine maker — Reducing HIV Recurrence
  8. Antiretroviral Therapy for the Prevention of HIV-1 Transmission - PMC
  9. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV - ClinicalInfo.HIV.gov - NCBI Bookshelf
  10. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society–USA Panel | HIV | JAMA | JAMA Network

Original Source(s)

Related Content