Acute acalculous cholecystitis in children due to EBV and cytomegalovirus infection: a rare case report and review of the literature - Report - MDSpire
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Acute acalculous cholecystitis in children due to EBV and cytomegalovirus infection: a rare case report and review of the literature
Clinical Report: A Rare Case of Acute Acalculous Cholecystitis in Pediatric Patients
Background
Acute cholecystitis is uncommon in pediatric patients, with acute acalculous cholecystitis being particularly rare. Viral infections, especially EBV and CMV, can complicate the clinical presentation, leading to missed diagnoses.
Data Highlights
Laboratory Findings
Results
Leukocytosis
Yes
Lymphocytosis
Marked
Atypical lymphocytes
Present
Elevated transaminases
Yes
Mild hyperbilirubinemia
Yes
Key Findings
A 7-year-old boy presented with fever, cervical lymphadenopathy, and abdominal pain.
Laboratory tests showed leukocytosis, lymphocytosis, and elevated liver enzymes.
Ultrasound revealed gallbladder wall thickening without gallstones, consistent with AAC.
EBV and CMV coinfection was confirmed through serological and molecular testing.
The patient improved with conservative management after discontinuation of antibiotics.
Clinical Implications
Healthcare providers should consider EBV and CMV as potential causes of AAC in pediatric patients presenting with infectious mononucleosis. Early recognition can prevent unnecessary antibiotic use and surgical interventions.
Conclusion
This case illustrates the occurrence of viral-associated AAC in children with infectious mononucleosis.
In a nationwide US cohort, parental subfecundity was associated with higher odds of autism spectrum disorder and modest increases in behavioral symptoms, while in vitro fertilization showed no statistically significant associations with neurodevelopmental outcomes.
