Clinical Report: The Role of Circular RNA circEVI5 in RCC Progression

Overview

This study identifies circEVI5 as an oncogenic driver in renal cell carcinoma (RCC), significantly upregulated in RCC tissues and associated with poor survival outcomes.

Background

Renal cell carcinoma (RCC) represents a significant global health burden, with high incidence and mortality rates. Current treatment options are limited, particularly for advanced stages of the disease. Understanding the molecular mechanisms underlying RCC progression is crucial for developing effective therapies.

Data Highlights

Key Findings

• CircEVI5 is significantly upregulated in RCC tissues and cell lines.
• Knockdown of circEVI5 inhibits cell viability, migration, and invasion in vitro.
• CircEVI5 acts as a sponge for miR-433, which is downregulated in RCC.
• GBP2 is identified as a target of miR-433 and is associated with reduced survival in RCC patients.
• Clinical correlations show that miR-433 levels are inversely correlated with both circEVI5 and GBP2.

Clinical Implications

The findings indicate the clinical relevance of circEVI5 in RCC.

Conclusion

CircEVI5 plays a critical role in RCC progression through its interaction with miR-433 and GBP2.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Frontiers in Immunology — Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer
3. Journal of Neuro-Oncology — CircHGF RNA Translation Produces an HGF Protein Variant that Enhances Glioblastoma Proliferation via c-MET Activation
4. Gastric Cancer — CircDUSP16 facilitates gastric cancer progression and invasion through miR-145-5p sponging
5. Archives of Toxicology — MKLN1 Circular RNA Enhances Epithelial-Mesenchymal Transition in Pulmonary Fibrosis by Modulating the miR-26a/b-5p/CDK8 Pathway in Human Alveolar Epithelial Cells and Animal Models
6. Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer
7. CircHGF RNA Translation Produces an HGF Protein Variant that Enhances Glioblastoma Proliferation via c-MET Activation
8. CircDUSP16 facilitates gastric cancer progression and invasion through miR-145-5p sponging
9. https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Renal-Cell-Carcinoma-2025_2025-04-17-105637_dkgm.pdf