Clinical Report: Impact of Resolved Hyperthyroidism on Cumulative Live Birth Rates in IVF
Overview
This study investigates the impact of hyperthyroidism on IVF outcomes, comparing women with active hyperthyroidism, resolved hyperthyroidism, and normal controls.
Background
Hyperthyroidism is a significant endocrine disorder affecting reproductive health, with prevalence rates among women of reproductive age ranging from 0.2% to 2.5%. Its effects on fertility and pregnancy outcomes are complex.
Data Highlights
Group
Fresh Cycle LBR
CLBR
Active Hyperthyroidism (AH)
31.9%
42.3%
Resolved Hyperthyroidism (RH)
-
44.1%
Normal Control (NC)
43.7%
54.9%
Key Findings
Fresh cycle live birth rate (LBR) was significantly lower in the AH group compared to NC (31.9% vs. 43.7%, P = 0.034). Cumulative live birth rates (CLBR) were 42.3% in AH, 44.1% in RH, and 54.9% in NC. Adjusted models showed lower LBR and CLBR in AH versus NC, with no significant differences between AH and RH. Longer duration of hyperthyroidism was negatively associated with CLBR (aOR=0.9990, P< 0.001). The study included 17,621 patients, with 257 in the AH group, 297 in the RH group, and 17,067 in the NC group.
Clinical Implications
The findings suggest that women with hyperthyroidism may experience poorer IVF outcomes, emphasizing the need for careful management of thyroid function prior to assisted reproductive treatments. Clinicians should consider the duration of hyperthyroidism when counseling patients regarding fertility options.
Conclusion
This study highlights the adverse effects of preconception hyperthyroidism on IVF outcomes, particularly the association between longer disease duration and lower cumulative live birth rates.
