Perceived stress and mental health in perimenopausal women: a serial mediation study of psychological distress and social support - Report - MDSpire

Perceived stress and mental health in perimenopausal women: a serial mediation study of psychological distress and social support

  • By

  • Tingting Ruan

  • Ying Yuan

  • Yiwei Li

  • Lijia Hou

  • Xuyan Liu

  • Shuling Ye

  • Jing Lu

  • Xue Tang

  • Yang Liu

  • May 20, 2026

  • 0 min

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Clinical Report: The Role of Perceived Stress and Mental Well-Being in Perimenopausal Women

Overview

This study investigates how perceived stress influences psychological symptom severity in perimenopausal women, particularly focusing on symptoms such as anxiety and depression, while highlighting the mediating roles of psychological distress and social support. Findings indicate that addressing these factors is crucial for improving mental health outcomes in this demographic.

Background

Perimenopause significantly impacts the mental health of women, with over 80% experiencing adverse symptoms such as anxiety and depression. The unique stressors during this phase, including career and family responsibilities, contribute to heightened perceived stress, a critical risk factor for mental health disorders like anxiety and depression. Understanding the mechanisms through which perceived stress affects mental health is essential for developing effective interventions.

Data Highlights

VariableCorrelationEffect SizePercentage
Perceived StressPositive with Psychological Distress0.49359.60%
Psychological DistressIndependent Mediator0.20424.67%
Perceived Social SupportIndependent Mediator0.10112.21%
Chain-Mediated PathwayIndirect Effect0.0303.62%

Key Findings

  • Perceived stress is positively correlated with psychological symptom severity in perimenopausal women.
  • Psychological distress and perceived social support independently mediate the relationship between perceived stress and psychological symptom severity.
  • Reducing psychological distress and enhancing social support can disrupt the cycle of stress and psychological symptoms.
  • The study emphasizes the need for a multifaceted approach to improve mental health in perimenopausal women, focusing on both psychological distress and social support.
  • Over 80% of perimenopausal women experience adverse mental health outcomes, highlighting the public health significance of this issue.

Clinical Implications

Healthcare providers should focus on assessing and addressing perceived stress and psychological distress in perimenopausal women. Implementing strategies such as support groups or counseling to enhance social support may also be beneficial in mitigating psychological symptoms during this transitional phase.

Conclusion

The findings underscore the importance of a comprehensive approach to mental health care for perimenopausal women, specifically targeting perceived stress, psychological distress, and social support to improve overall well-being.

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  5. NG23 Menopause: Full guideline 2015
  6. ScienceDirect, 2026 -- Prevalence and incidence of depressive, anxiety, and insomnia symptoms in perimenopausal and postmenopausal women: Systematic review and meta-analysis
  7. Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial
  8. NG23 Menopause: Full guideline 2015
  9. Prevalence and incidence of depressive, anxiety, and insomnia symptoms in perimenopausal and postmenopausal women: Systematic review and meta-analysis - ScienceDirect
  10. Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial

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