Case Report: A case of incidentally discovered isolated gastric plasmacytoma - Report - MDSpire

Case Report: A case of incidentally discovered isolated gastric plasmacytoma

  • By

  • Ya-nan Zhang

  • Qing-xin Li

  • Lin-chong Ma

  • Yong-tai Jin

  • Wen-qi Li

  • Jin-chen Du

  • July 7, 2026

  • 0 min

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Clinical Report: An Incidentally Identified Isolated Gastric Plasmacytoma

Background

Extramedullary plasmacytoma (EMP) is a rare plasma cell malignancy, with gastric plasmacytoma being an uncommon subtype. It often presents with nonspecific gastrointestinal symptoms, leading to potential misdiagnosis. Understanding its clinical features and diagnostic approaches is crucial for effective management.

Data Highlights

No numerical or trial data presented in the article.

Key Findings

  • Gastric plasmacytoma accounts for approximately 2% of EMP cases.
  • The diagnosis relies on histopathology, immunohistochemistry, and exclusion of multiple myeloma.
  • Endoscopic mucosal resection was performed for the lesion in this case.
  • Primary gastric plasmacytoma often presents with nonspecific upper gastrointestinal symptoms.
  • There is a lack of uniform treatment guidelines for gastric plasmacytoma.

Clinical Implications

Accurate diagnosis requires a thorough workup to exclude multiple myeloma and other conditions.

Conclusion

This case highlights the importance of recognizing isolated gastric plasmacytoma and the need for comprehensive diagnostic approaches in similar clinical scenarios.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf
  3. the new gastroenterologist — Case study: Gastric ulcer mimicking malignancy
  4. Gastric Cancer — Case Study of Multiple Foveolar-Type Gastric Adenomas in a Patient Without Helicobacter pylori Infection Following Prolonged Proton Pump Inhibitor Therapy
  5. Frontiers in Oncology — Case Report: Not all signet rings are of gastric origin: a case of lobular breast carcinoma metastatic to the stomach
  6. Journal of Gastrointestinal Surgery — Gastric Glomus Tumor: A Case Study with Imaging Findings
  7. Case study: Gastric ulcer mimicking malignancy
  8. Case Study of Multiple Foveolar-Type Gastric Adenomas in a Patient Without Helicobacter pylori Infection Following Prolonged Proton Pump Inhibitor Therapy
  9. Case Report: Not all signet rings are of gastric origin: a case of lobular breast carcinoma metastatic to the stomach
  10. Therapeutic options for extramedullary involvement in multiple myeloma | Clinical and Experimental Medicine | Springer Nature Link
  11. Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf

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