Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents - Report - MDSpire

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • By

  • Kostinov, Mikhail

  • Prutskova, Ekaterina

  • Mekhantseva, Irina

  • Cherdantsev, Alexander

  • Solovеva, Irina

  • Polishchuk, Valentina

  • Zhestkov, Alexander

  • Khamidulina, Anna

  • Dementeva, Yuliya

  • Kostinov, Anton

  • Khrapunova, Isabella

  • Loktionova, Marina

  • Tarasova, Alla

  • Kvasova, Maria

  • Poddubikov, Arseniy

  • Pal, Nidhi Harish

  • Kostinova, Aristitsa

  • June 2, 2026

  • 0 min

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Clinical Report: Assessment of Specific IgG Levels Pre- and Post-Booster Vaccination

Overview

This study evaluated the immunological response to booster vaccinations for diphtheria, tetanus, and pertussis in 14-year-old adolescents. Results indicated increases in diphtheria and tetanus IgG levels, while pertussis responses were heterogeneous and showed no significant increase post-vaccination.

Background

Maintaining durable immunity against diphtheria, tetanus, and pertussis is essential for adolescent health and public safety. This study addresses the gap in knowledge regarding the effectiveness of pertussis booster vaccination in adolescents.

Data Highlights

Vaccine TypeParticipantsAnti-Diphtheria IgG IncreaseAnti-Tetanus IgG LevelsPertussis IgG Response
Td-M34Robust IncreaseHighest TitersNo Significant Increase
Tdap51Robust IncreaseHigh LevelsNo Significant Increase
Tdap-M36Robust IncreaseHigh LevelsNo Significant Increase

Key Findings

  • All participants had protective immunity to tetanus at baseline.
  • 1.7% lacked protective antibody levels against diphtheria.
  • 6.9% lacked protective antibody levels against pertussis.
  • Booster vaccination significantly increased anti-diphtheria IgG levels across all groups.
  • All vaccines were well tolerated with only mild adverse events reported.
  • Pertussis-specific IgG responses were heterogeneous with no overall increase post-vaccination.

Clinical Implications

The study highlights the importance of booster vaccinations in reinforcing immunity against diphtheria and tetanus in adolescents. However, the limited response to pertussis vaccination suggests a need for reevaluation of booster strategies for this disease.

Conclusion

Adolescent booster vaccinations enhance immunity against diphtheria and tetanus, but the lack of significant pertussis response raises questions.

Related Resources & Content

  1. Open Forum Infectious Diseases, 2024 -- Diphtheria Seroprevalence in Children Aged 3 to 15 in Antananarivo, Madagascar, and Cambodia
  2. Frontiers in Immunology, 2026 -- Preclinical Study on an Adsorbed Acellular Diphtheria-Tetanus-Pertussis (Reduced-Dose) Combined Vaccine: Evaluation of Reproductive safety and Immunogenicity
  3. Open Forum Infectious Diseases, 2024 -- Assessment of the Effectiveness of Three Acellular Pertussis Vaccines in Children Aged 3 Months to 16 Years in Lu’an, China: A Matched Case-Control Analysis
  4. The Journal of Infectious Diseases, 2024 -- The Effect of Pertussis Vaccination During Pregnancy on the Binding Epitopes and Avidity of Anti–Pertussis Toxin Immunoglobulin G Antibodies in Infants and Their Mothers
  5. Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger, 2025 | MMWR
  6. Pertussis - Annual Epidemiological Report for 2024
  7. Chapter 16: Pertussis | Pink Book | CDC
  8. Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger — United States, 2025 | MMWR
  9. Pertussis - Annual Epidemiological Report for 2024
  10. Chapter 16: Pertussis | Pink Book | CDC

Original Source(s)

Specific IgG levels before and one month after administration of a booster dose of the diphtheria, tetanus, and pertussis vaccine in 14-year-old adolescents

  • by Kostinov, Mikhail , Prutskova, Ekaterina , Mekhantseva, Irina , Cherdantsev, Alexander , Solovеva, Irina , Polishchuk, Valentina , Zhestkov, Alexander , Khamidulina, Anna , Dementeva, Yuliya , Kostinov, Anton , Khrapunova, Isabella , Loktionova, Marina , Tarasova, Alla , Kvasova, Maria , Poddubikov, Arseniy , Pal, Nidhi Harish, Kostinova, Aristitsa

  • June 2, 2026

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