Clinical Report: Link Between SIRI and NLPR Levels and Post-Operative Pneumonia

Overview

This study evaluates the association of the Systemic Inflammation Response Index (SIRI) and the Neutrophil-to-Lymphocyte-to-Platelet Ratio (NLPR) with hospital-acquired post-operative pneumonia (POP) in middle-aged and elderly patients following hip fracture surgery.

Background

Post-operative pneumonia is a common complication after hip fracture surgery, significantly impacting patient outcomes and healthcare resources.

Data Highlights

Key Findings

• 25 out of 452 patients (5.53%) developed post-operative pneumonia.
• SIRI and NLPR were positively associated with the risk of pneumonia after hip fracture surgery.
• Both SIRI and NLPR exhibited moderate discriminative performance (AUC: 0.701 and 0.738, respectively).
• An NLPR above 2.879 was significantly linked to increased incidence of POP (OR = 5.47).
• The difference in AUC between SIRI and NLPR was not statistically significant (P = 0.247).

Clinical Implications

The findings suggest that SIRI and NLPR could be useful in identifying patients at risk for post-operative pneumonia following hip fracture surgery. Their moderate predictive ability may assist clinicians in stratifying risk and implementing preventive strategies.

Conclusion

SIRI and NLPR are associated with hospital-acquired post-operative pneumonia in middle-aged and elderly patients after hip fracture surgery.

Related Resources & Content

1. Frontiers in Medicine, 2026 -- Elevated neutrophil percentage–to–albumin ratio is associated with postoperative pneumonia in patients with hip fractures
2. Frontiers in Medicine, 2026 -- Preoperative neutrophil-to-lymphocyte ratio and systemic immune-inflammation index as prognostic biomarkers for postoperative pneumonia and pulmonary complications after thoracic surgery: a systematic review and meta-analysis
3. Updates in Surgery (Springer), 2026 -- Surgical stabilization of rib fractures in older adults: a retrospective cohort study
4. PubMed, 2025 -- The risk of complications after hip fracture
5. Infectious Diseases Society of America, 2016 -- Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines
6. Frontiers in Medicine, 2026 -- Association of SIRI and NLPR with postoperative pneumonia in middle-aged and elderly patients after hip fracture surgery
7. Incidence of Surgical Site Infections Following Hip Hemiarthroplasty for Femoral Neck Fractures: A Systematic Review and Meta-Analysis
8. The risk of complications after hip fracture - PubMed
9. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
10. Frontiers | Association of SIRI and NLPR with postoperative pneumonia in middle-aged and elderly patients after hip fracture surgery