Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis - Report - MDSpire

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis

  • By

  • Hiromu Fukuda

  • Yoshito Hayashi

  • Shinji Yoneda

  • Yujiro Adachi

  • Ayaka Tajiri

  • Eiji Kimura

  • Ryotaro Uema

  • Takeo Yoshihara

  • Yoshiki Tsujii

  • Takahiro Kodama

  • Tetsuo Takehara

  • June 29, 2026

  • 0 min

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Assessment of Lymph Node Metastasis Risk in Early-Onset T1 Colorectal Cancer

Overview

This systematic review and meta-analysis evaluates lymph node metastasis (LNM) rates in early-onset (EO) versus late-onset (LO) T1 colorectal cancer (CRC).

Background

Colorectal cancer (CRC) is increasingly diagnosed in younger individuals, with early-onset CRC (EO-CRC) representing about 10% of cases. EO-CRC often presents at more advanced stages, leading to poorer outcomes. Understanding the risk of lymph node metastasis (LNM) in T1 CRC is essential for tailoring treatment and surveillance protocols.

Data Highlights

No specific numerical data or trial results were provided in the source material.

Key Findings

  • EO-CRC is diagnosed at a more advanced stage compared to LO-CRC.
  • LNM occurs in approximately 10% of patients with T1 CRC.
  • Age has not been commonly considered a risk factor for LNM in T1 CRC.
  • There is a lack of consensus on management strategies for EO-T1 CRC compared to LO-T1 CRC.
  • Assessment of LNM risk is crucial for determining management in T1 CRC patients.

Clinical Implications

Further research is needed to establish age-specific management protocols for T1 CRC.

Conclusion

This study highlights the need for more focused research on lymph node metastasis in early-onset T1 CRC to inform treatment strategies.

Related Resources & Content

  1. A novel clinical framework for forecasting lymph node metastasis in T1 colorectal carcinoma, 2024 -- https://link.springer.com/article/10.1007/s00384-024-04621-y
  2. Identifying Risk Factors for Lymph Node Metastasis in Early Colorectal Cancer: Development of a Predictive Nomogram and Risk Evaluation, 2024 -- https://link.springer.com/article/10.1007/s00384-024-04760-2
  3. Impact of Lymph Node Retrieval on Cancer-Specific Survival in T1 Colorectal Cancer Patients: Insights from a U.S. Database and Chinese Registry Analysis, 2025 -- https://link.springer.com/article/10.1007/s00384-025-04816-x
  4. Assessment of Lymph Node Metastasis in T1 Colorectal Cancer Utilizing Body Composition and Vascular Invasion Factors, 2024 -- https://link.springer.com/article/10.1007/s00384-024-04653-4
  5. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) -- https://crain-platform-precisiononcologynews-prod.s3.amazonaws.com/2025-04/NCCN%20colon%20DPYD%20update%20033125.pdf?utm_source=openai
  6. Histopathological risk factors for lymph node metastases in T1 colorectal cancer: meta-analysis - PubMed -- https://pubmed.ncbi.nlm.nih.gov/34244752/?utm_source=openai
  7. Colorectal Cancer Statistics, 2026
  8. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®)
  9. Histopathological risk factors for lymph node metastases in T1 colorectal cancer: meta-analysis - PubMed

Original Source(s)

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis

  • by Hiromu Fukuda, Yoshito Hayashi, Shinji Yoneda, Yujiro Adachi, Ayaka Tajiri, Eiji Kimura, Ryotaro Uema, Takeo Yoshihara, Yoshiki Tsujii, Takahiro Kodama, Tetsuo Takehara

  • June 29, 2026

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