Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry - Report - MDSpire

Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry

  • By

  • Antonio Vitale

  • Valeria Caggiano

  • Jessica Sbalchiero

  • Francesco Gavioli

  • Giuseppe Lopalco

  • Gaafar Ragab

  • Silvana Guerriero

  • Ibrahim Almaglouth

  • Abdurrahman Tufan

  • Roberto Giacomelli

  • Haner Direskeneli

  • Piero Ruscitti

  • Gülen Hatemi

  • Francesco Carubbi

  • Ezgi Deniz Batu

  • Seza Ozen

  • Jurgen Sota

  • Henrique Ayres Mayrink Giardini

  • Micol Frassi

  • Petros P Sfikakis

  • Maria Morrone

  • Federica Gatti

  • Amina Maher

  • Ayman Abdel-Monem Ahmed Mahmoud

  • Rosanna Dammacco

  • Hamit Kucuk

  • Riza Can Kardas

  • Ibrahim Yahya Cakir

  • Letizia Pia di Corcia

  • Fatma Alibaz Öner

  • Gizem Sevik

  • Martina Gentile

  • Alican Karakoc

  • Alessia Alunno

  • Hulya Ercan Emreol

  • Francesca Crisafulli

  • Maria Tektonidou

  • Francesco Ciccia

  • Maissa Thabet

  • Serena Bugatti

  • Alessandra Milanesi

  • Maria Sole Chimenti

  • Benedetta Monosi

  • Matteo Piga

  • Alberto Floris

  • Andrea Hinojosa-Azaola

  • Guillermo Arturo Guaracha-Basañez

  • Cecilia Beatrice Chighizola

  • José Hernández-Rodríguez

  • Marco Cattalini

  • Marcello Govoni

  • Ombretta Viapiana

  • Adele Civino

  • Daniela Opris-Belinski

  • Carla Gaggiano

  • Rosaria Talarico

  • Annarita Giardina

  • Giacomo Emmi

  • Piercarlo Sarzi Puttini

  • Maria Cristina Maggio

  • Paola Parronchi

  • Piero Portincasa

  • Alejandra de-la-Torre

  • Juanita Cardona-López

  • Stefano Gentileschi

  • Angela Mauro

  • Gian Domenico Sebastiani

  • Maria Francesca Gicchino

  • Ali Şahin

  • Donato Rigante

  • Emre Bilgin

  • Emanuela Del Giudice

  • Luciana Breda

  • Amato De Paulis

  • Alberto Lo Gullo

  • Şükran Erten

  • Samar Tharwat

  • Lampros Fotis

  • Maier Armin

  • Antonella Insalaco

  • Anastasios Karamanakos

  • Alessandro Conforti

  • Özgül Soysal Gündüz

  • Abdelhfeez Moshrif

  • Francesca Li Gobbi

  • Stefania Costi

  • Elena Bartoloni

  • Patrizia Barone

  • Serena Guiducci

  • Andrés González-García

  • Inés Hernanz Rodriguez

  • Giovanni Conti

  • Annamaria Iagnocco

  • Fatos Önen

  • Sulaiman M. Al-Mayouf

  • Ali İbrahim Hatemi

  • Alberto Balistreri

  • Claudia Fabiani

  • Luca Cantarini

  • May 13, 2026

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Clinical Report: Assessing the Likelihood of Gastrointestinal Involvement in Mucocutaneous Behçet’s Disease

Overview

This study identifies key demographic and clinical factors associated with gastrointestinal involvement in Behçet’s disease (BD) patients who initially present with mucocutaneous symptoms. Notably, significant oral aphthosis is a strong predictor of later gastrointestinal complications.

Background

Behçet’s disease is a systemic condition that can manifest with various symptoms, including mucocutaneous lesions. Understanding the progression from mucocutaneous to gastrointestinal involvement is crucial, as gastrointestinal complications can lead to severe health risks. Identifying clinical features that predict this progression can enhance patient monitoring and treatment strategies.

Data Highlights

VariableOdds Ratio (OR)95% Credible Interval (CrI)Posterior Probability
Intestinal involvement3.021.24–6.0899.3%
Minor aphthous ulcers0.470.22–0.9897.98%
Major aphthous ulcers3.251.50–7.0299.7%
Oral major aphthosis + genital aphthosis2.771.14–6.5898.45%
Pseudofolliculitis + oral major aphthosis3.181.15–8.3398.72%
Pseudofolliculitis + other cutaneous manifestations0.010.0–0.9897.55%

Key Findings

  • 14% of patients with mucocutaneous onset developed gastrointestinal involvement.
  • Significant oral aphthosis is the strongest predictor of gastrointestinal complications.
  • Minor aphthous ulcers are protective against intestinal involvement.
  • Major aphthous ulcers increase the risk of gastrointestinal manifestations.
  • Combinations of mucocutaneous features significantly affect the likelihood of intestinal involvement.
  • Gastrointestinal involvement correlates with a higher risk of ocular inflammation.

Clinical Implications

Clinicians should closely monitor patients with Behçet’s disease who present with significant oral aphthosis, as they are at increased risk for gastrointestinal complications. Early identification of at-risk patients can facilitate timely interventions and improve management strategies.

Conclusion

The findings underscore the importance of recognizing specific mucocutaneous manifestations in Behçet’s disease, as they can indicate a higher likelihood of gastrointestinal involvement and associated complications. Continuous clinical vigilance is essential for optimal patient care.

Related Resources & Content

  1. Journal of Gastroenterology, 2020 -- Clinical Practice Guidelines and Evidence-Based Diagnostic Approaches for Intestinal Behçet's Disease
  2. Journal of Crohn's and Colitis -- Correlation Between Histological and Endoscopic Findings in a Prospective Study of Patients With Inflammatory Bowel Diseases
  3. Techniques in Coloproctology -- A National Multicenter Evaluation of the Simplified Histologic Mucosal Healing Scheme (SHMHS) for Inflammatory Bowel Disease
  4. Clinical Rheumatology -- Exploring the Relationship Between MALAT1 and miRNA-155 for Identifying Diagnostic and Prognostic Biomarkers in Behçet’s Disease
  5. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome | Annals of the Rheumatic Diseases
  6. Trial of Apremilast for Oral Ulcers in Behçet's Syndrome.
  7. Frontiers | Risk of Intestinal Involvement in Mucocutaneous-Onset Behçet’s Disease: data from the AIDA Network Registry
  8. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome | Annals of the Rheumatic Diseases
  9. Trial of Apremilast for Oral Ulcers in Behçet's Syndrome.
  10. Frontiers | Risk of Intestinal Involvement in Mucocutaneous-Onset Behçet’s Disease: data from the AIDA Network Registry

Original Source(s)

Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry

  • by Antonio Vitale, Valeria Caggiano, Jessica Sbalchiero, Francesco Gavioli, Giuseppe Lopalco, Gaafar Ragab, Silvana Guerriero, Ibrahim Almaglouth, Abdurrahman Tufan, Roberto Giacomelli, Haner Direskeneli, Piero Ruscitti, Gülen Hatemi, Francesco Carubbi, Ezgi Deniz Batu, Seza Ozen, Jurgen Sota, Henrique Ayres Mayrink Giardini, Micol Frassi, Petros P Sfikakis, Maria Morrone, Federica Gatti, Amina Maher, Ayman Abdel-Monem Ahmed Mahmoud, Rosanna Dammacco, Hamit Kucuk, Riza Can Kardas, Ibrahim Yahya Cakir, Letizia Pia di Corcia, Fatma Alibaz Öner, Gizem Sevik, Martina Gentile, Alican Karakoc, Alessia Alunno, Hulya Ercan Emreol, Francesca Crisafulli, Maria Tektonidou, Francesco Ciccia, Maissa Thabet, Serena Bugatti, Alessandra Milanesi, Maria Sole Chimenti, Benedetta Monosi, Matteo Piga, Alberto Floris, Andrea Hinojosa-Azaola, Guillermo Arturo Guaracha-Basañez, Cecilia Beatrice Chighizola, José Hernández-Rodríguez, Marco Cattalini, Marcello Govoni, Ombretta Viapiana, Adele Civino, Daniela Opris-Belinski, Carla Gaggiano, Rosaria Talarico, Annarita Giardina, Giacomo Emmi, Piercarlo Sarzi Puttini, Maria Cristina Maggio, Paola Parronchi, Piero Portincasa, Alejandra de-la-Torre, Juanita Cardona-López, Stefano Gentileschi, Angela Mauro, Gian Domenico Sebastiani, Maria Francesca Gicchino, Ali Şahin, Donato Rigante, Emre Bilgin, Emanuela Del Giudice, Luciana Breda, Amato De Paulis, Alberto Lo Gullo, Şükran Erten, Samar Tharwat, Lampros Fotis, Maier Armin, Antonella Insalaco, Anastasios Karamanakos, Alessandro Conforti, Özgül Soysal Gündüz, Abdelhfeez Moshrif, Francesca Li Gobbi, Stefania Costi, Elena Bartoloni, Patrizia Barone, Serena Guiducci, Andrés González-García, Inés Hernanz Rodriguez, Giovanni Conti, Annamaria Iagnocco, Fatos Önen, Sulaiman M. Al-Mayouf, Ali İbrahim Hatemi, Alberto Balistreri, Claudia Fabiani, Luca Cantarini

  • May 13, 2026

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