Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation - Report - MDSpire

Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation

  • By

  • Michael Koechlin

  • Rebecca E. Paladini

  • Stefanie Aeschbacher

  • Christine S. Zuern

  • Ivo Strebel

  • Michael Coslovsky

  • Matea Liskij

  • Ruben Kerler

  • Philipp Krisai

  • Leo H. Bonati

  • David Conen

  • Felix Mahfoud

  • Stefan Osswald

  • Michael Kühne

  • Beat A. Kaufmann

  • July 1, 2026

  • 0 min

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Clinical Report: Evaluation of Mitral and Tricuspid Regurgitation Progression

Overview

This study evaluates the progression of mitral and tricuspid regurgitation in patients with atrial fibrillation (AF) compared to those without. Findings indicate that AF is associated with higher rates of tricuspid regurgitation progression.

Background

Mitral and tricuspid regurgitation are prevalent valvular disorders that can worsen over time, particularly in the context of atrial fibrillation (AF). This study provides longitudinal data on the rates of progression in patients with and without AF.

Data Highlights

ConditionAF Progression Rate (per 100 person-years)Non-AF Progression Rate (per 100 person-years)
Any MR Progression7.315.0
Clinically Relevant MR Progression3.33.9
Any TR Progression9.98.9
Clinically Relevant TR Progression5.22.1

Key Findings

  • AF was associated with a higher likelihood of any tricuspid regurgitation progression.
  • Clinically relevant progression of tricuspid regurgitation was also more common in patients with AF.
  • No significant association was found between AF and progression of mitral regurgitation.
  • The study included 412 patients from the Swiss-AF and BEAT-AF cohorts.
  • The median age of participants was 74 years, with 26% being female.

Clinical Implications

The findings indicate that tricuspid regurgitation progression is higher in patients with atrial fibrillation.

Conclusion

This study highlights the differential impact of atrial fibrillation on the progression of tricuspid versus mitral regurgitation.

Related Resources & Content

  1. Clinical Research in Cardiology, 2026 -- Improvement of functional mitral and tricuspid regurgitation in patients with atrial fibrillation after sinus rhythm restoration—the Berlin FMTR registry
  2. Clinical Research in Cardiology, 2025 -- Prioritizing Atrial Fibrillation: Examining Rhythm Management in Newly Diagnosed High-Grade Functional Mitral Regurgitation with Atrial Fibrillation
  3. Frontiers in Cardiovascular Medicine, 2026 -- A comparison of the severity of tricuspid valve regurgitation between echocardiographic and cardiac magnetic resonance criteria in adults with congenital heart disease
  4. 2025 ESC/EACTS Guidelines for the management of valvular heart disease
  5. Clinical Research in Cardiology — Effects of Sinus Rhythm Compared to Atrial Fibrillation on Left Ventricular Remodeling Following Transcatheter Aortic Valve Replacement
  6. Minimally Invasive Valve Repair Reduces Heart Failure Hospitalizations in Patients with Severe Tricuspid Regurgitation - American College of Cardiology
  7. 2025 ESC/EACTS Guidelines for the management of valvular heart disease
  8. 700.38 Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation: An Updated Meta-Analysis | JACC: Cardiovascular Interventions

Original Source(s)

Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation

  • by Michael Koechlin, Rebecca E. Paladini, Stefanie Aeschbacher, Christine S. Zuern, Ivo Strebel, Michael Coslovsky, Matea Liskij, Ruben Kerler, Philipp Krisai, Leo H. Bonati, David Conen, Felix Mahfoud, Stefan Osswald, Michael Kühne, Beat A. Kaufmann

  • July 1, 2026

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