Clinical Report: Hydrocephalus as a Reliable Indicator of In-Hospital Mortality in Tuberculous Meningitis

Overview

This study investigates the association between hydrocephalus and in-hospital mortality in non-HIV patients with tuberculous meningitis (TBM).

Background

Tuberculous meningitis (TBM) is a severe form of tuberculosis with high mortality rates, often exacerbated by complications such as hydrocephalus. Understanding the prognostic factors associated with TBM is crucial for improving patient outcomes. Hydrocephalus, a common complication, has been recognized as a key adverse prognostic factor.

Data Highlights

Key Findings

• Hydrocephalus is independently associated with increased in-hospital mortality in TBM patients.
• The in-hospital mortality rate among the studied cohort was 11.9%.
• No statistically significant interaction between hydrocephalus and age was detected.
• Predicted mortality increased with older age in both hydrocephalus groups.
• The prediction model demonstrated excellent discrimination and good calibration.

Clinical Implications

The findings suggest that clinicians should prioritize the early detection and management of hydrocephalus in TBM patients, regardless of age. Understanding the consistent impact of hydrocephalus on mortality can guide treatment decisions and resource allocation.

Conclusion

Hydrocephalus serves as a predictor of in-hospital mortality in patients with tuberculous meningitis.

Related Resources & Content

1. Author(s)/Org, Source, Year -- Title
2. Author(s)/Org, The Journal of Infectious Diseases, 2023 -- Tuberculous Meningitis Across the Lifespan
3. Author(s)/Org, Frontiers in Pediatrics, 2023 -- Case Report: Tuberculous meningitis presenting with multifocal cerebral infarction and hydrocephalus in a toddler
4. Author(s)/Org, The Journal of Infectious Diseases, 2023 -- Cerebrospinal Fluid Low-Grade Inflammation Contributes to Mortality in Tuberculous Meningitis Among HIV Patients
5. Author(s)/Org, Annals of Intensive Care, 2025 -- Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis
6. International TBM Clinical Practice Guidelines
7. Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis | Annals of Intensive Care | Springer Nature Link
8. Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults | New England Journal of Medicine